Knockdown of cytokeratin 8 overcomes chemoresistance of chordoma cells by aggravating endoplasmic reticulum stress through PERK/eIF2α arm of unfolded protein response and blocking autophagy

Chordoma is a malignant primary osseous spinal tumor with pronounced chemoresistance. However, the mechanisms of how chordoma cells develop chemoresistance are still not fully understood. Cytokeratin 8 (KRT8) is a molecular marker of notochordal cells, from which chordoma cells were believed to be o...

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Detalles Bibliográficos
Autores principales: Wang, Di, Zhang, Peiran, Xu, Xiaolong, Wang, Jianhui, Wang, Dong, Peng, Pandi, Zheng, Chao, Meng, Qing-Jun, Yang, Liu, Luo, Zhuojing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877560/
https://www.ncbi.nlm.nih.gov/pubmed/31767864
http://dx.doi.org/10.1038/s41419-019-2125-9

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