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Applying the Fokker–Planck equation to grating-based x-ray phase and dark-field imaging
X-ray imaging has conventionally relied upon attenuation to provide contrast. In recent years, two complementary modalities have been added; (a) phase contrast, which can capture low-density samples that are difficult to see using attenuation, and (b) dark-field x-ray imaging, which reveals the pres...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877582/ https://www.ncbi.nlm.nih.gov/pubmed/31767904 http://dx.doi.org/10.1038/s41598-019-52283-6 |
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author | Morgan, Kaye S. Paganin, David M. |
author_facet | Morgan, Kaye S. Paganin, David M. |
author_sort | Morgan, Kaye S. |
collection | PubMed |
description | X-ray imaging has conventionally relied upon attenuation to provide contrast. In recent years, two complementary modalities have been added; (a) phase contrast, which can capture low-density samples that are difficult to see using attenuation, and (b) dark-field x-ray imaging, which reveals the presence of sub-pixel sample structures. These three modalities can be accessed using a crystal analyser, a grating interferometer or by looking at a directly-resolved grid, grating or speckle pattern. Grating and grid-based methods extract a differential phase signal by measuring how far a feature in the illumination has been shifted transversely due to the presence of a sample. The dark-field signal is extracted by measuring how the visibility of the structured illumination is decreased, typically due to the presence of sub-pixel structures in a sample. The strength of the dark-field signal may depend on the grating period, the pixel size and the set-up distances, and additional dark-field signal contributions may be seen as a result of strong phase effects or other factors. In this paper we show that the finite-difference form of the Fokker–Planck equation can be applied to describe the drift (phase signal) and diffusion (dark-field signal) of the periodic or structured illumination used in phase contrast x-ray imaging with gratings, in order to better understand any cross-talk between attenuation, phase and dark-field x-ray signals. In future work, this mathematical description could be used as a basis for new approaches to the inverse problem of recovering both phase and dark-field information. |
format | Online Article Text |
id | pubmed-6877582 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-68775822019-12-05 Applying the Fokker–Planck equation to grating-based x-ray phase and dark-field imaging Morgan, Kaye S. Paganin, David M. Sci Rep Article X-ray imaging has conventionally relied upon attenuation to provide contrast. In recent years, two complementary modalities have been added; (a) phase contrast, which can capture low-density samples that are difficult to see using attenuation, and (b) dark-field x-ray imaging, which reveals the presence of sub-pixel sample structures. These three modalities can be accessed using a crystal analyser, a grating interferometer or by looking at a directly-resolved grid, grating or speckle pattern. Grating and grid-based methods extract a differential phase signal by measuring how far a feature in the illumination has been shifted transversely due to the presence of a sample. The dark-field signal is extracted by measuring how the visibility of the structured illumination is decreased, typically due to the presence of sub-pixel structures in a sample. The strength of the dark-field signal may depend on the grating period, the pixel size and the set-up distances, and additional dark-field signal contributions may be seen as a result of strong phase effects or other factors. In this paper we show that the finite-difference form of the Fokker–Planck equation can be applied to describe the drift (phase signal) and diffusion (dark-field signal) of the periodic or structured illumination used in phase contrast x-ray imaging with gratings, in order to better understand any cross-talk between attenuation, phase and dark-field x-ray signals. In future work, this mathematical description could be used as a basis for new approaches to the inverse problem of recovering both phase and dark-field information. Nature Publishing Group UK 2019-11-25 /pmc/articles/PMC6877582/ /pubmed/31767904 http://dx.doi.org/10.1038/s41598-019-52283-6 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Morgan, Kaye S. Paganin, David M. Applying the Fokker–Planck equation to grating-based x-ray phase and dark-field imaging |
title | Applying the Fokker–Planck equation to grating-based x-ray phase and dark-field imaging |
title_full | Applying the Fokker–Planck equation to grating-based x-ray phase and dark-field imaging |
title_fullStr | Applying the Fokker–Planck equation to grating-based x-ray phase and dark-field imaging |
title_full_unstemmed | Applying the Fokker–Planck equation to grating-based x-ray phase and dark-field imaging |
title_short | Applying the Fokker–Planck equation to grating-based x-ray phase and dark-field imaging |
title_sort | applying the fokker–planck equation to grating-based x-ray phase and dark-field imaging |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877582/ https://www.ncbi.nlm.nih.gov/pubmed/31767904 http://dx.doi.org/10.1038/s41598-019-52283-6 |
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