Design of a New [PSI(+)]-No-More Mutation in SUP35 With Strong Inhibitory Effect on the [PSI(+)] Prion Propagation

A number of [PSI(+)]-no-more (PNM) mutations, eliminating [PSI(+)] prion, were previously described in SUP35. In this study, we designed and analyzed a new PNM mutation based on the parallel in-register β-structure of Sup35 prion fibrils suggested by the known experimental data. In such an arrangeme...

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Detalles Bibliográficos
Autores principales: Danilov, Lavrentii G., Matveenko, Andrew G., Ryzhkova, Varvara E., Belousov, Mikhail V., Poleshchuk, Olga I., Likholetova, Daria V., Sokolov, Petr A., Kasyanenko, Nina A., Kajava, Andrey V., Zhouravleva, Galina A., Bondarev, Stanislav A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877606/
https://www.ncbi.nlm.nih.gov/pubmed/31803017
http://dx.doi.org/10.3389/fnmol.2019.00274

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