Loss of ubiquitin-conjugating enzyme E2 (Ubc9) in macrophages exacerbates multiple low-dose streptozotocin-induced diabetes by attenuating M2 macrophage polarization

Type 1 diabetes (T1D) is characterized by the selective autoimmune destruction of the islet β cells, and macrophages play a significant role in this process. Small ubiquitin-like modification (SUMOylation) is an important posttranslational modification involved in T1D pathogenesis, but its function...

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Detalles Bibliográficos
Autores principales: Wang, Faxi, Sun, Fei, Luo, Jiahui, Yue, Tiantian, Chen, Longmin, Zhou, Haifeng, Zhang, Jing, Yang, Chunliang, Luo, Xi, Zhou, Qing, Zhu, He, Li, Jinxiu, Yang, Ping, Xiong, Fei, Yu, Qilin, Zhang, Huilan, Zhang, Wanguang, Xu, Aimin, Zhou, Zhiguang, Lu, Qianjin, Eizirik, Decio L., Zhang, Shu, Wang, Cong-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877645/
https://www.ncbi.nlm.nih.gov/pubmed/31767832
http://dx.doi.org/10.1038/s41419-019-2130-z

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