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Melatonin and Rapamycin Attenuate Isoflurane-Induced Cognitive Impairment Through Inhibition of Neuroinflammation by Suppressing the mTOR Signaling in the Hippocampus of Aged Mice

Melatonin exerts neuroprotective effects on isoflurane-induced cognitive impairment. However, the underlying mechanism has yet to be elucidated. The present study sought to determine if melatonin confers its beneficial effects by acting on mammalian target of rapamycin (mTOR) and attenuates the neur...

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Detalles Bibliográficos
Autores principales:	Yuan, Hui, Wu, Guorong, Zhai, Xiaojie, Lu, Bo, Meng, Bo, Chen, Junping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877689/ https://www.ncbi.nlm.nih.gov/pubmed/31803045 http://dx.doi.org/10.3389/fnagi.2019.00314

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