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Impacto de una intervención farmacéutica en la prevención de recaídas en depresión en atención primaria()
OBJECTIVE: To evaluate the long-term impact of a brief pharmacist intervention (PI) compared with usual care (UC) on prevention of depression relapse. DESIGN: randomised controlled clinical trial SETTING: Primary Care PARTICIPANTS: Of the 179 depressed patients initiating antidepressants, the 113 wh...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877882/ https://www.ncbi.nlm.nih.gov/pubmed/26415743 http://dx.doi.org/10.1016/j.aprim.2015.05.009 |
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author | Rubio-Valera, María Peñarrubia-María, M. Teresa Fernández-Vergel, Rita Carvajal Tejadillo, Andrea Cecilia Fernández Sánchez, Ana Aznar-Lou, Ignacio March-Pujol, Marian Serrano-Blanco, Antoni |
author_facet | Rubio-Valera, María Peñarrubia-María, M. Teresa Fernández-Vergel, Rita Carvajal Tejadillo, Andrea Cecilia Fernández Sánchez, Ana Aznar-Lou, Ignacio March-Pujol, Marian Serrano-Blanco, Antoni |
author_sort | Rubio-Valera, María |
collection | PubMed |
description | OBJECTIVE: To evaluate the long-term impact of a brief pharmacist intervention (PI) compared with usual care (UC) on prevention of depression relapse. DESIGN: randomised controlled clinical trial SETTING: Primary Care PARTICIPANTS: Of the 179 depressed patients initiating antidepressants, the 113 whose clinical symptoms had remitted (main definition) at 6 months assessment were selected for this secondary study (PI = 58; UC = 55). INTERVENTION: PI was an interview to promote medication adherence when patients get antidepressants from pharmacy. MAIN MEASUREMENTS: Baseline, 3 months, and six-months follow-up assessments were made. The severity of depressive symptoms was evaluated with PHQ9. Patients presenting a remission of symptoms were selected. The patient medical records were reviewed to identify a relapse in the following 12 months by using 4 indicators. RESULTS: There was a lower proportion of patients that relapsed in the PI group than in the UC group 18 months after initiation of treatment, but the difference was not statistically significant either in the intent-to-treat analysis (OR = 0.734 [95%CI; 0.273-1.975]) or the per-protocol analysis (OR = 0.615 [95%CI; 0.183 -2.060]). All the sensitivity analyses showed consistent results. The sample size and adherence to the protocol in the intervention group were low. CONCLUSION: PI group showed a non-statistically significant tendency towards presenting fewer relapses. This could be related to the improvement in adherence among patients that received the intervention. |
format | Online Article Text |
id | pubmed-6877882 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-68778822019-11-29 Impacto de una intervención farmacéutica en la prevención de recaídas en depresión en atención primaria() Rubio-Valera, María Peñarrubia-María, M. Teresa Fernández-Vergel, Rita Carvajal Tejadillo, Andrea Cecilia Fernández Sánchez, Ana Aznar-Lou, Ignacio March-Pujol, Marian Serrano-Blanco, Antoni Aten Primaria Originales OBJECTIVE: To evaluate the long-term impact of a brief pharmacist intervention (PI) compared with usual care (UC) on prevention of depression relapse. DESIGN: randomised controlled clinical trial SETTING: Primary Care PARTICIPANTS: Of the 179 depressed patients initiating antidepressants, the 113 whose clinical symptoms had remitted (main definition) at 6 months assessment were selected for this secondary study (PI = 58; UC = 55). INTERVENTION: PI was an interview to promote medication adherence when patients get antidepressants from pharmacy. MAIN MEASUREMENTS: Baseline, 3 months, and six-months follow-up assessments were made. The severity of depressive symptoms was evaluated with PHQ9. Patients presenting a remission of symptoms were selected. The patient medical records were reviewed to identify a relapse in the following 12 months by using 4 indicators. RESULTS: There was a lower proportion of patients that relapsed in the PI group than in the UC group 18 months after initiation of treatment, but the difference was not statistically significant either in the intent-to-treat analysis (OR = 0.734 [95%CI; 0.273-1.975]) or the per-protocol analysis (OR = 0.615 [95%CI; 0.183 -2.060]). All the sensitivity analyses showed consistent results. The sample size and adherence to the protocol in the intervention group were low. CONCLUSION: PI group showed a non-statistically significant tendency towards presenting fewer relapses. This could be related to the improvement in adherence among patients that received the intervention. Elsevier 2016-05 2015-09-26 /pmc/articles/PMC6877882/ /pubmed/26415743 http://dx.doi.org/10.1016/j.aprim.2015.05.009 Text en © 2015 Elsevier España, S.L.U. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Originales Rubio-Valera, María Peñarrubia-María, M. Teresa Fernández-Vergel, Rita Carvajal Tejadillo, Andrea Cecilia Fernández Sánchez, Ana Aznar-Lou, Ignacio March-Pujol, Marian Serrano-Blanco, Antoni Impacto de una intervención farmacéutica en la prevención de recaídas en depresión en atención primaria() |
title | Impacto de una intervención farmacéutica en la prevención de recaídas en depresión en atención primaria() |
title_full | Impacto de una intervención farmacéutica en la prevención de recaídas en depresión en atención primaria() |
title_fullStr | Impacto de una intervención farmacéutica en la prevención de recaídas en depresión en atención primaria() |
title_full_unstemmed | Impacto de una intervención farmacéutica en la prevención de recaídas en depresión en atención primaria() |
title_short | Impacto de una intervención farmacéutica en la prevención de recaídas en depresión en atención primaria() |
title_sort | impacto de una intervención farmacéutica en la prevención de recaídas en depresión en atención primaria() |
topic | Originales |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877882/ https://www.ncbi.nlm.nih.gov/pubmed/26415743 http://dx.doi.org/10.1016/j.aprim.2015.05.009 |
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