A rare case of idiopathic cholestasis: Clinical conundrums complicating enzalutamide therapy in metastatic prostate cancer

Current safety data affirms enzalutamide does not cause clinically significant liver dysfunction that warrant therapy cessation. Therefore, clinicians should not withhold potentially successful therapy merely for suspected hepatotoxicity or PnC.

Detalles Bibliográficos
Autores principales: Liu, Jun, Agyapong, George, Misra, Debashish, Taylor, C. Douglas, Hirsh, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878062/
https://www.ncbi.nlm.nih.gov/pubmed/31788253
http://dx.doi.org/10.1002/ccr3.2427
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author Liu, Jun
Agyapong, George
Misra, Debashish
Taylor, C. Douglas
Hirsh, David A.
author_facet Liu, Jun
Agyapong, George
Misra, Debashish
Taylor, C. Douglas
Hirsh, David A.
author_sort Liu, Jun
collection PubMed
description Current safety data affirms enzalutamide does not cause clinically significant liver dysfunction that warrant therapy cessation. Therefore, clinicians should not withhold potentially successful therapy merely for suspected hepatotoxicity or PnC.
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spelling pubmed-68780622019-11-29 A rare case of idiopathic cholestasis: Clinical conundrums complicating enzalutamide therapy in metastatic prostate cancer Liu, Jun Agyapong, George Misra, Debashish Taylor, C. Douglas Hirsh, David A. Clin Case Rep Case Reports Current safety data affirms enzalutamide does not cause clinically significant liver dysfunction that warrant therapy cessation. Therefore, clinicians should not withhold potentially successful therapy merely for suspected hepatotoxicity or PnC. John Wiley and Sons Inc. 2019-09-26 /pmc/articles/PMC6878062/ /pubmed/31788253 http://dx.doi.org/10.1002/ccr3.2427 Text en © 2019 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Liu, Jun
Agyapong, George
Misra, Debashish
Taylor, C. Douglas
Hirsh, David A.
A rare case of idiopathic cholestasis: Clinical conundrums complicating enzalutamide therapy in metastatic prostate cancer
title A rare case of idiopathic cholestasis: Clinical conundrums complicating enzalutamide therapy in metastatic prostate cancer
title_full A rare case of idiopathic cholestasis: Clinical conundrums complicating enzalutamide therapy in metastatic prostate cancer
title_fullStr A rare case of idiopathic cholestasis: Clinical conundrums complicating enzalutamide therapy in metastatic prostate cancer
title_full_unstemmed A rare case of idiopathic cholestasis: Clinical conundrums complicating enzalutamide therapy in metastatic prostate cancer
title_short A rare case of idiopathic cholestasis: Clinical conundrums complicating enzalutamide therapy in metastatic prostate cancer
title_sort rare case of idiopathic cholestasis: clinical conundrums complicating enzalutamide therapy in metastatic prostate cancer
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878062/
https://www.ncbi.nlm.nih.gov/pubmed/31788253
http://dx.doi.org/10.1002/ccr3.2427
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