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F8-IL10: A New Potential Antirheumatic Drug Evaluated by a PET-Guided Translational Approach

[Image: see text] Antibody fragment F8-mediated interleukin 10 (IL10) delivery is a novel treatment for rheumatoid arthritis (RA). F8 binds to the extra-domain-A of fibronectin (ED-A). In this study, in vivo biodistribution and arthritis targeting of radiolabeled F8-IL10 were investigated in RA pati...

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Detalles Bibliográficos
Autores principales:	Bruijnen, Stefan T.G., Chandrupatla, Durga M.S.H., Giovanonni, Leonardo, Neri, Dario, Vugts, Danielle J., Huisman, Marc C., Hoekstra, Otto S., Musters, René J.P., Lammertsma, Adriaan A., van Dongen, Guus A.M.S., Jansen, Gerrit, Molthoff, Carla F.M., van der Laken, Conny J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878215/ https://www.ncbi.nlm.nih.gov/pubmed/30550295 http://dx.doi.org/10.1021/acs.molpharmaceut.8b00982

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