The AKT isoforms 1 and 2 drive B cell fate decisions during the germinal center response

The PI3K pathway is integral for the germinal center (GC) response. However, the contribution of protein kinase B (AKT) as a PI3K effector in GC B cells remains unknown. Here, we show that mice lacking the AKT1 and AKT2 isoforms in B cells failed to form GCs, which undermined affinity maturation and...

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Detalles Bibliográficos
Autores principales: Zhu, Zilu, Shukla, Ashima, Ramezani-Rad, Parham, Apgar, John R, Rickert, Robert C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878223/
https://www.ncbi.nlm.nih.gov/pubmed/31767615
http://dx.doi.org/10.26508/lsa.201900506

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