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Serum Neuron-specific Enolase and S100 Calcium-binding Protein B in Pediatric Diabetic Ketoacidosis

OBJECTIVE: Neuron-specific enolase (NSE) and S100 calcium-binding protein B (S100B) are markers of different neurological disorders. The aim was to investigate the relationship between NSE and S100B serum concentrations and the severity of diabetic ketoacidosis (DKA) in diabetic children. METHODS: E...

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Autores principales: Elshorbagy, Hatem Hamed, Barseem, Naglaa Fathy, Elsadek, Akram Elshafey, Al-shokary, Ashraf Hamed, Maksoud, Yehia Hamed Abdel, Abdulsamea, Sameh Elsayed, Talaat, Iman M., Suliman, Hany Abdelaziz, Kamal, Naglaa M., Abdelghani, Waleed E., Azab, Sanaa Mohammed, El Din, Dalia Mohamed Nour
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878350/
https://www.ncbi.nlm.nih.gov/pubmed/31067852
http://dx.doi.org/10.4274/jcrpe.galenos.2019.2018.0280
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author Elshorbagy, Hatem Hamed
Barseem, Naglaa Fathy
Elsadek, Akram Elshafey
Al-shokary, Ashraf Hamed
Maksoud, Yehia Hamed Abdel
Abdulsamea, Sameh Elsayed
Talaat, Iman M.
Suliman, Hany Abdelaziz
Kamal, Naglaa M.
Abdelghani, Waleed E.
Azab, Sanaa Mohammed
El Din, Dalia Mohamed Nour
author_facet Elshorbagy, Hatem Hamed
Barseem, Naglaa Fathy
Elsadek, Akram Elshafey
Al-shokary, Ashraf Hamed
Maksoud, Yehia Hamed Abdel
Abdulsamea, Sameh Elsayed
Talaat, Iman M.
Suliman, Hany Abdelaziz
Kamal, Naglaa M.
Abdelghani, Waleed E.
Azab, Sanaa Mohammed
El Din, Dalia Mohamed Nour
author_sort Elshorbagy, Hatem Hamed
collection PubMed
description OBJECTIVE: Neuron-specific enolase (NSE) and S100 calcium-binding protein B (S100B) are markers of different neurological disorders. The aim was to investigate the relationship between NSE and S100B serum concentrations and the severity of diabetic ketoacidosis (DKA) in diabetic children. METHODS: Eighty children with DKA, 40 with type 1 diabetes mellitus (T1DM) without DKA and 40 healthy controls were enrolled. Severity of DKA was assessed according to blood pH and bicarbonate concentration. Serum NSE and S100B were measured in all participants. In the DKA group serum NSE and S100B were measured at three time points, at admission and at 12 hours and 24 hours after starting treatment. RESULTS: Children with DKA showed significantly higher serum levels of NSE at all time points compared to children with T1DM without DKA and controls (p<0.01), while serum S100B concentrations did not differ between the three cohorts. Children with T1DM but without DKA also had significantly higher serum levels of NSE (p<0.01) compared to healthy controls. Patients with low Glasgow Coma Scale score (GCSS) and those with moderate and severe DKA had significantly higher levels of NSE at all time points (p<0.01 for each) compared to patients with normal GCSS and those with mild DKA. No significant differences were found in serum S100B levels according to the severity of DKA and GCS (p>0.05). Younger age, lower GCSS, higher glucose and HbA1c, lower pH and lower serum bicarbonate were the risk factors associated with elevated NSE. CONCLUSION: Serum NSE is elevated in all patients with type 1 DM and, in patients with DKA, correlates with severity of DKA. However, serum S100B concentration did not differ between T1DM with or without DKA and healthy controls.
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spelling pubmed-68783502019-12-04 Serum Neuron-specific Enolase and S100 Calcium-binding Protein B in Pediatric Diabetic Ketoacidosis Elshorbagy, Hatem Hamed Barseem, Naglaa Fathy Elsadek, Akram Elshafey Al-shokary, Ashraf Hamed Maksoud, Yehia Hamed Abdel Abdulsamea, Sameh Elsayed Talaat, Iman M. Suliman, Hany Abdelaziz Kamal, Naglaa M. Abdelghani, Waleed E. Azab, Sanaa Mohammed El Din, Dalia Mohamed Nour J Clin Res Pediatr Endocrinol Original Article OBJECTIVE: Neuron-specific enolase (NSE) and S100 calcium-binding protein B (S100B) are markers of different neurological disorders. The aim was to investigate the relationship between NSE and S100B serum concentrations and the severity of diabetic ketoacidosis (DKA) in diabetic children. METHODS: Eighty children with DKA, 40 with type 1 diabetes mellitus (T1DM) without DKA and 40 healthy controls were enrolled. Severity of DKA was assessed according to blood pH and bicarbonate concentration. Serum NSE and S100B were measured in all participants. In the DKA group serum NSE and S100B were measured at three time points, at admission and at 12 hours and 24 hours after starting treatment. RESULTS: Children with DKA showed significantly higher serum levels of NSE at all time points compared to children with T1DM without DKA and controls (p<0.01), while serum S100B concentrations did not differ between the three cohorts. Children with T1DM but without DKA also had significantly higher serum levels of NSE (p<0.01) compared to healthy controls. Patients with low Glasgow Coma Scale score (GCSS) and those with moderate and severe DKA had significantly higher levels of NSE at all time points (p<0.01 for each) compared to patients with normal GCSS and those with mild DKA. No significant differences were found in serum S100B levels according to the severity of DKA and GCS (p>0.05). Younger age, lower GCSS, higher glucose and HbA1c, lower pH and lower serum bicarbonate were the risk factors associated with elevated NSE. CONCLUSION: Serum NSE is elevated in all patients with type 1 DM and, in patients with DKA, correlates with severity of DKA. However, serum S100B concentration did not differ between T1DM with or without DKA and healthy controls. Galenos Publishing 2019-12 2019-11-22 /pmc/articles/PMC6878350/ /pubmed/31067852 http://dx.doi.org/10.4274/jcrpe.galenos.2019.2018.0280 Text en ©Copyright 2019 by Turkish Pediatric Endocrinology and Diabetes Society | The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Elshorbagy, Hatem Hamed
Barseem, Naglaa Fathy
Elsadek, Akram Elshafey
Al-shokary, Ashraf Hamed
Maksoud, Yehia Hamed Abdel
Abdulsamea, Sameh Elsayed
Talaat, Iman M.
Suliman, Hany Abdelaziz
Kamal, Naglaa M.
Abdelghani, Waleed E.
Azab, Sanaa Mohammed
El Din, Dalia Mohamed Nour
Serum Neuron-specific Enolase and S100 Calcium-binding Protein B in Pediatric Diabetic Ketoacidosis
title Serum Neuron-specific Enolase and S100 Calcium-binding Protein B in Pediatric Diabetic Ketoacidosis
title_full Serum Neuron-specific Enolase and S100 Calcium-binding Protein B in Pediatric Diabetic Ketoacidosis
title_fullStr Serum Neuron-specific Enolase and S100 Calcium-binding Protein B in Pediatric Diabetic Ketoacidosis
title_full_unstemmed Serum Neuron-specific Enolase and S100 Calcium-binding Protein B in Pediatric Diabetic Ketoacidosis
title_short Serum Neuron-specific Enolase and S100 Calcium-binding Protein B in Pediatric Diabetic Ketoacidosis
title_sort serum neuron-specific enolase and s100 calcium-binding protein b in pediatric diabetic ketoacidosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878350/
https://www.ncbi.nlm.nih.gov/pubmed/31067852
http://dx.doi.org/10.4274/jcrpe.galenos.2019.2018.0280
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