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mTOR activation due to APPL1 deficiency exacerbates hyperalgesia via Rab5/Akt and AMPK signaling pathway in streptozocin-induced diabetic rats

Painful diabetic neuropathy is a common complication of diabetes mellitus with obscure underlying mechanisms. The adaptor protein APPL1 is critical in mediating the insulin sensitizing and insulin signaling. In neurons, APPL1 reportedly affects synaptic plasticity, while its role in the pathogenesis...

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Detalles Bibliográficos
Autores principales:	He, Wan-You, Zhang, Bin, Zhao, Wei-Cheng, He, Jian, Wang, Yunhua, Zhang, Lei, Xiong, Qing-Ming, Wang, Han-Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878613/ https://www.ncbi.nlm.nih.gov/pubmed/31530215 http://dx.doi.org/10.1177/1744806919880643

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