The pathogenesis of renal injury and treatment in light chain deposition disease

Light chain deposition disease (LCDD) is a rare clinical disorder. The deposition of light chain immunoglobulins mainly affects the kidneys, which have different characteristics than other tissues. To date, the therapeutic approach for the treatment of LCDD has no evidence-based consensus, and clini...

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Detalles Bibliográficos
Autores principales: Wang, Qi, Jiang, Fang, Xu, Gaosi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878616/
https://www.ncbi.nlm.nih.gov/pubmed/31767034
http://dx.doi.org/10.1186/s12967-019-02147-4
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author Wang, Qi
Jiang, Fang
Xu, Gaosi
author_facet Wang, Qi
Jiang, Fang
Xu, Gaosi
author_sort Wang, Qi
collection PubMed
description Light chain deposition disease (LCDD) is a rare clinical disorder. The deposition of light chain immunoglobulins mainly affects the kidneys, which have different characteristics than other tissues. To date, the therapeutic approach for the treatment of LCDD has no evidence-based consensus, and clinical experience of reported cases guides current disease management strategies. The present systematic review investigates and summarizes the pathological mechanisms of renal injury and the subsequent treatments for LCDD.
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spelling pubmed-68786162019-11-29 The pathogenesis of renal injury and treatment in light chain deposition disease Wang, Qi Jiang, Fang Xu, Gaosi J Transl Med Review Light chain deposition disease (LCDD) is a rare clinical disorder. The deposition of light chain immunoglobulins mainly affects the kidneys, which have different characteristics than other tissues. To date, the therapeutic approach for the treatment of LCDD has no evidence-based consensus, and clinical experience of reported cases guides current disease management strategies. The present systematic review investigates and summarizes the pathological mechanisms of renal injury and the subsequent treatments for LCDD. BioMed Central 2019-11-25 /pmc/articles/PMC6878616/ /pubmed/31767034 http://dx.doi.org/10.1186/s12967-019-02147-4 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Wang, Qi
Jiang, Fang
Xu, Gaosi
The pathogenesis of renal injury and treatment in light chain deposition disease
title The pathogenesis of renal injury and treatment in light chain deposition disease
title_full The pathogenesis of renal injury and treatment in light chain deposition disease
title_fullStr The pathogenesis of renal injury and treatment in light chain deposition disease
title_full_unstemmed The pathogenesis of renal injury and treatment in light chain deposition disease
title_short The pathogenesis of renal injury and treatment in light chain deposition disease
title_sort pathogenesis of renal injury and treatment in light chain deposition disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878616/
https://www.ncbi.nlm.nih.gov/pubmed/31767034
http://dx.doi.org/10.1186/s12967-019-02147-4
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