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MSC-secreted TGF-β regulates lipopolysaccharide-stimulated macrophage M2-like polarization via the Akt/FoxO1 pathway

BACKGROUND: An uncontrolled inflammatory response is a critical pathophysiological feature of sepsis. Mesenchymal stem cells (MSCs) induce macrophage phenotype polarization and reduce inflammation in sepsis. MSC-secreted transforming growth factor beta (TGF-β) participated in the immune modulatory f...

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Detalles Bibliográficos
Autores principales:	Liu, Feng, Qiu, Haibo, Xue, Ming, Zhang, Shi, Zhang, Xiwen, Xu, Jingyuan, Chen, Jianxiao, Yang, Yi, Xie, Jianfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878630/ https://www.ncbi.nlm.nih.gov/pubmed/31771622 http://dx.doi.org/10.1186/s13287-019-1447-y

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