Prostate Cancer-associated SPOP mutations enhance cancer cell survival and docetaxel resistance by upregulating Caprin1-dependent stress granule assembly

BACKGROUND: The gene encoding the E3 ubiquitin ligase substrate-binding adaptor SPOP is frequently mutated in primary prostate cancer, but how SPOP mutations contribute to prostate cancer pathogenesis remains poorly understood. Stress granules (SG) assembly is an evolutionarily conserved strategy fo...

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Detalles Bibliográficos
Autores principales: Shi, Qing, Zhu, Yasheng, Ma, Jian, Chang, Kun, Ding, Dongling, Bai, Yang, Gao, Kun, Zhang, Pingzhao, Mo, Ren, Feng, Kai, Zhao, Xiaying, Zhang, Liang, Sun, Huiru, Jiao, Dongyue, Chen, Yingji, Sun, Yinghao, Zhao, Shi-min, Huang, Haojie, Li, Yao, Ren, Shancheng, Wang, Chenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878651/
https://www.ncbi.nlm.nih.gov/pubmed/31771591
http://dx.doi.org/10.1186/s12943-019-1096-x

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