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Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice
OBJECTIVE: Dietary intervention is a practical prevention strategy for age-related hearing loss (AHL). Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) may be effective in prevention of AHL due to their anti-inflammatory and tissue-protective functions. Age-related changes in the hearing function o...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878677/ https://www.ncbi.nlm.nih.gov/pubmed/31771637 http://dx.doi.org/10.1186/s13104-019-4809-8 |
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author | Honkura, Yohei Suzuki, Jun Sakayori, Nobuyuki Inada, Hitoshi Kawase, Tetsuaki Katori, Yukio Osumi, Noriko |
author_facet | Honkura, Yohei Suzuki, Jun Sakayori, Nobuyuki Inada, Hitoshi Kawase, Tetsuaki Katori, Yukio Osumi, Noriko |
author_sort | Honkura, Yohei |
collection | PubMed |
description | OBJECTIVE: Dietary intervention is a practical prevention strategy for age-related hearing loss (AHL). Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) may be effective in prevention of AHL due to their anti-inflammatory and tissue-protective functions. Age-related changes in the hearing function of wild-type and Fat-1 transgenic mice derived from the C57BL/6N strain, which can convert omega-6 PUFAs to n-3 PUFAs and consequently produce enriched endogenous n-3 PUFAs, were investigated to test the efficacy of n-3 PUFAs for AHL prevention. RESULTS: At 2 months, the baseline auditory brainstem response (ABR) thresholds were the same in Fat-1 and wild-type mice at 8–16 kHz but were significantly higher in Fat-1 mice at 4 and 32 kHz. In contrast, the ABR thresholds of Fat-1 mice were significantly lower at 10 months. Moreover, the ABR thresholds of Fat-1 mice at low-middle frequencies were significantly lower at 13 months (12 kHz). Body weights were significantly reduced in Fat-1 mice at 13 months, but not at 2, 10, and 16–17 months. In conclusion, enriched endogenous n-3 PUFAs produced due to the expression of the Fat-1 transgene partially alleviated AHL in male C57BL/6N mice. |
format | Online Article Text |
id | pubmed-6878677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-68786772019-11-29 Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice Honkura, Yohei Suzuki, Jun Sakayori, Nobuyuki Inada, Hitoshi Kawase, Tetsuaki Katori, Yukio Osumi, Noriko BMC Res Notes Research Note OBJECTIVE: Dietary intervention is a practical prevention strategy for age-related hearing loss (AHL). Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) may be effective in prevention of AHL due to their anti-inflammatory and tissue-protective functions. Age-related changes in the hearing function of wild-type and Fat-1 transgenic mice derived from the C57BL/6N strain, which can convert omega-6 PUFAs to n-3 PUFAs and consequently produce enriched endogenous n-3 PUFAs, were investigated to test the efficacy of n-3 PUFAs for AHL prevention. RESULTS: At 2 months, the baseline auditory brainstem response (ABR) thresholds were the same in Fat-1 and wild-type mice at 8–16 kHz but were significantly higher in Fat-1 mice at 4 and 32 kHz. In contrast, the ABR thresholds of Fat-1 mice were significantly lower at 10 months. Moreover, the ABR thresholds of Fat-1 mice at low-middle frequencies were significantly lower at 13 months (12 kHz). Body weights were significantly reduced in Fat-1 mice at 13 months, but not at 2, 10, and 16–17 months. In conclusion, enriched endogenous n-3 PUFAs produced due to the expression of the Fat-1 transgene partially alleviated AHL in male C57BL/6N mice. BioMed Central 2019-11-26 /pmc/articles/PMC6878677/ /pubmed/31771637 http://dx.doi.org/10.1186/s13104-019-4809-8 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Note Honkura, Yohei Suzuki, Jun Sakayori, Nobuyuki Inada, Hitoshi Kawase, Tetsuaki Katori, Yukio Osumi, Noriko Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice |
title | Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice |
title_full | Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice |
title_fullStr | Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice |
title_full_unstemmed | Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice |
title_short | Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice |
title_sort | effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice |
topic | Research Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878677/ https://www.ncbi.nlm.nih.gov/pubmed/31771637 http://dx.doi.org/10.1186/s13104-019-4809-8 |
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