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Onychomadesis and potential association with HFMD outbreak in a kindergarten in Hubei province, China, 2017

BACKGROUND: In 2017, an outbreak of onychomadesis occurred in kindergarten H, Hubei province, China. We investigated the field to learn about the magnitude and reason of the outbreak. METHODS: The case definition was that a child with onychomadesis or transverse ridging (Beau’s line) in fingernails...

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Autores principales: Li, Dan, Wu, Yang, Xing, Xuesen, Huang, Jigui, Mao, Anlu, Liu, Tian, Rao, Ping, Qin, Wei, Zhang, Lijie, Feng, Luzhao, Gao, Shangren, Guan, Xuhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878681/
https://www.ncbi.nlm.nih.gov/pubmed/31771520
http://dx.doi.org/10.1186/s12879-019-4560-8
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author Li, Dan
Wu, Yang
Xing, Xuesen
Huang, Jigui
Mao, Anlu
Liu, Tian
Rao, Ping
Qin, Wei
Zhang, Lijie
Feng, Luzhao
Gao, Shangren
Guan, Xuhua
author_facet Li, Dan
Wu, Yang
Xing, Xuesen
Huang, Jigui
Mao, Anlu
Liu, Tian
Rao, Ping
Qin, Wei
Zhang, Lijie
Feng, Luzhao
Gao, Shangren
Guan, Xuhua
author_sort Li, Dan
collection PubMed
description BACKGROUND: In 2017, an outbreak of onychomadesis occurred in kindergarten H, Hubei province, China. We investigated the field to learn about the magnitude and reason of the outbreak. METHODS: The case definition was that a child with onychomadesis or transverse ridging (Beau’s line) in fingernails and toenails without previous traumatic or systemic disease in kindergarten H from Sep. 1st to Nov. 30th, 2017. A retrospective cohort study was carried out to analyze the epidemiological relationship between onychomadesis and the hand-foot-mouth disease (HFMD) in Primary Class #2, kindergarten H. We also performed a serological survey for neutralizing antibodies against coxsackie virus A6 (CVA6), coxsackie virus A10 (CVA10) among 15 cases and six healthy children in the kindergarten. Meanwhile, some children were carried out with routine blood, fungal microscopic and microelement tests. Indoor environment examinations had been done for all classes. RESULTS: A total of 20 cases were identified in Kindergarten H. Seventy-five percent (15/20) cases occurred in Primary Class #2. Fifty-five percent of the cases (11/20) had suffered from HFMD within two months. The median time between onychomadesis and HFMD was 45 days (ranging from 31 to 58 days). A retrospective cohort study in Primary Class #2 showed the attack rate was 90.0% among 10 children who suffered from HFMD in the past two months compared to 30.0% among 20 children who didn’t (Rate Ratio [RR] =3.0, 95% Confidence Interval [CI] =1.5–6.0). The positive rates of neutralizing antibodies were 66.7% for CVA6 and 26.7% for CVA10 in tested cases. The result of routine blood, fungal microscopic, microelements tests were normal in cases. The indicators of environment were within the normal range. CONCLUSION: The results of this study suggested that the outbreak of onychomadesis in Hubei province was probably associated with HFMD epidemic within two months.
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spelling pubmed-68786812019-11-29 Onychomadesis and potential association with HFMD outbreak in a kindergarten in Hubei province, China, 2017 Li, Dan Wu, Yang Xing, Xuesen Huang, Jigui Mao, Anlu Liu, Tian Rao, Ping Qin, Wei Zhang, Lijie Feng, Luzhao Gao, Shangren Guan, Xuhua BMC Infect Dis Research Article BACKGROUND: In 2017, an outbreak of onychomadesis occurred in kindergarten H, Hubei province, China. We investigated the field to learn about the magnitude and reason of the outbreak. METHODS: The case definition was that a child with onychomadesis or transverse ridging (Beau’s line) in fingernails and toenails without previous traumatic or systemic disease in kindergarten H from Sep. 1st to Nov. 30th, 2017. A retrospective cohort study was carried out to analyze the epidemiological relationship between onychomadesis and the hand-foot-mouth disease (HFMD) in Primary Class #2, kindergarten H. We also performed a serological survey for neutralizing antibodies against coxsackie virus A6 (CVA6), coxsackie virus A10 (CVA10) among 15 cases and six healthy children in the kindergarten. Meanwhile, some children were carried out with routine blood, fungal microscopic and microelement tests. Indoor environment examinations had been done for all classes. RESULTS: A total of 20 cases were identified in Kindergarten H. Seventy-five percent (15/20) cases occurred in Primary Class #2. Fifty-five percent of the cases (11/20) had suffered from HFMD within two months. The median time between onychomadesis and HFMD was 45 days (ranging from 31 to 58 days). A retrospective cohort study in Primary Class #2 showed the attack rate was 90.0% among 10 children who suffered from HFMD in the past two months compared to 30.0% among 20 children who didn’t (Rate Ratio [RR] =3.0, 95% Confidence Interval [CI] =1.5–6.0). The positive rates of neutralizing antibodies were 66.7% for CVA6 and 26.7% for CVA10 in tested cases. The result of routine blood, fungal microscopic, microelements tests were normal in cases. The indicators of environment were within the normal range. CONCLUSION: The results of this study suggested that the outbreak of onychomadesis in Hubei province was probably associated with HFMD epidemic within two months. BioMed Central 2019-11-26 /pmc/articles/PMC6878681/ /pubmed/31771520 http://dx.doi.org/10.1186/s12879-019-4560-8 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Li, Dan
Wu, Yang
Xing, Xuesen
Huang, Jigui
Mao, Anlu
Liu, Tian
Rao, Ping
Qin, Wei
Zhang, Lijie
Feng, Luzhao
Gao, Shangren
Guan, Xuhua
Onychomadesis and potential association with HFMD outbreak in a kindergarten in Hubei province, China, 2017
title Onychomadesis and potential association with HFMD outbreak in a kindergarten in Hubei province, China, 2017
title_full Onychomadesis and potential association with HFMD outbreak in a kindergarten in Hubei province, China, 2017
title_fullStr Onychomadesis and potential association with HFMD outbreak in a kindergarten in Hubei province, China, 2017
title_full_unstemmed Onychomadesis and potential association with HFMD outbreak in a kindergarten in Hubei province, China, 2017
title_short Onychomadesis and potential association with HFMD outbreak in a kindergarten in Hubei province, China, 2017
title_sort onychomadesis and potential association with hfmd outbreak in a kindergarten in hubei province, china, 2017
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878681/
https://www.ncbi.nlm.nih.gov/pubmed/31771520
http://dx.doi.org/10.1186/s12879-019-4560-8
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