A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation

Eleven new tetrahydrobenzo[b]pyran derivatives were synthesized via a three component reaction of different aromatic aldehydes, methyl cyanoacetate and 1,3-cyclohexadione, with water as solvent under catalyst-free microwave irradiation. The structures of all the new molecules were well analysed and...

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Autores principales: Khumalo, Mandlenkosi Robert, Maddila, Surya Narayana, Maddila, Suresh, Jonnalagadda, Sreekantha B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878704/
https://www.ncbi.nlm.nih.gov/pubmed/31788672
http://dx.doi.org/10.1186/s13065-019-0651-2
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author Khumalo, Mandlenkosi Robert
Maddila, Surya Narayana
Maddila, Suresh
Jonnalagadda, Sreekantha B.
author_facet Khumalo, Mandlenkosi Robert
Maddila, Surya Narayana
Maddila, Suresh
Jonnalagadda, Sreekantha B.
author_sort Khumalo, Mandlenkosi Robert
collection PubMed
description Eleven new tetrahydrobenzo[b]pyran derivatives were synthesized via a three component reaction of different aromatic aldehydes, methyl cyanoacetate and 1,3-cyclohexadione, with water as solvent under catalyst-free microwave irradiation. The structures of all the new molecules were well analysed and their structures established by using various spectral techniques ((1)H NMR, (13)C NMR, (15)N NMR and HRMS). Various advantages of reported protocol are the ease of preparation, short reaction times (10 min), aqueous solvent and excellent yields (89–98%). Additionally, this method provides a clean access to the desired products by simple workup. [Image: see text]
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spelling pubmed-68787042019-11-29 A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation Khumalo, Mandlenkosi Robert Maddila, Surya Narayana Maddila, Suresh Jonnalagadda, Sreekantha B. BMC Chem Research Article Eleven new tetrahydrobenzo[b]pyran derivatives were synthesized via a three component reaction of different aromatic aldehydes, methyl cyanoacetate and 1,3-cyclohexadione, with water as solvent under catalyst-free microwave irradiation. The structures of all the new molecules were well analysed and their structures established by using various spectral techniques ((1)H NMR, (13)C NMR, (15)N NMR and HRMS). Various advantages of reported protocol are the ease of preparation, short reaction times (10 min), aqueous solvent and excellent yields (89–98%). Additionally, this method provides a clean access to the desired products by simple workup. [Image: see text] Springer International Publishing 2019-11-26 /pmc/articles/PMC6878704/ /pubmed/31788672 http://dx.doi.org/10.1186/s13065-019-0651-2 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Khumalo, Mandlenkosi Robert
Maddila, Surya Narayana
Maddila, Suresh
Jonnalagadda, Sreekantha B.
A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation
title A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation
title_full A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation
title_fullStr A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation
title_full_unstemmed A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation
title_short A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation
title_sort facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878704/
https://www.ncbi.nlm.nih.gov/pubmed/31788672
http://dx.doi.org/10.1186/s13065-019-0651-2
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