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Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging

Oxidative stress is characterized by an imbalance between prooxidant and antioxidant species, leading to macromolecular damage and disruption of redox signaling and cellular control. It is a hallmark of various diseases including metabolic syndrome, chronic fatigue syndrome, neurodegenerative, cardi...

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Autores principales: Sztretye, Mónika, Dienes, Beatrix, Gönczi, Mónika, Czirják, Tamás, Csernoch, László, Dux, László, Szentesi, Péter, Keller-Pintér, Anikó
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878783/
https://www.ncbi.nlm.nih.gov/pubmed/31814873
http://dx.doi.org/10.1155/2019/3849692
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author Sztretye, Mónika
Dienes, Beatrix
Gönczi, Mónika
Czirják, Tamás
Csernoch, László
Dux, László
Szentesi, Péter
Keller-Pintér, Anikó
author_facet Sztretye, Mónika
Dienes, Beatrix
Gönczi, Mónika
Czirják, Tamás
Csernoch, László
Dux, László
Szentesi, Péter
Keller-Pintér, Anikó
author_sort Sztretye, Mónika
collection PubMed
description Oxidative stress is characterized by an imbalance between prooxidant and antioxidant species, leading to macromolecular damage and disruption of redox signaling and cellular control. It is a hallmark of various diseases including metabolic syndrome, chronic fatigue syndrome, neurodegenerative, cardiovascular, inflammatory, and age-related diseases. Several mitochondrial defects have been considered to contribute to the development of oxidative stress and known as the major mediators of the aging process and subsequent age-associated diseases. Thus, mitochondrial-targeted antioxidants should prevent or slow down these processes and prolong longevity. This is the reason why antioxidant treatments are extensively studied and newer and newer compounds with such an effect appear. Astaxanthin, a xanthophyll carotenoid, is the most abundant carotenoid in marine organisms and is one of the most powerful natural compounds with remarkable antioxidant activity. Here, we summarize its antioxidant targets, effects, and benefits in diseases and with aging.
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spelling pubmed-68787832019-12-08 Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging Sztretye, Mónika Dienes, Beatrix Gönczi, Mónika Czirják, Tamás Csernoch, László Dux, László Szentesi, Péter Keller-Pintér, Anikó Oxid Med Cell Longev Review Article Oxidative stress is characterized by an imbalance between prooxidant and antioxidant species, leading to macromolecular damage and disruption of redox signaling and cellular control. It is a hallmark of various diseases including metabolic syndrome, chronic fatigue syndrome, neurodegenerative, cardiovascular, inflammatory, and age-related diseases. Several mitochondrial defects have been considered to contribute to the development of oxidative stress and known as the major mediators of the aging process and subsequent age-associated diseases. Thus, mitochondrial-targeted antioxidants should prevent or slow down these processes and prolong longevity. This is the reason why antioxidant treatments are extensively studied and newer and newer compounds with such an effect appear. Astaxanthin, a xanthophyll carotenoid, is the most abundant carotenoid in marine organisms and is one of the most powerful natural compounds with remarkable antioxidant activity. Here, we summarize its antioxidant targets, effects, and benefits in diseases and with aging. Hindawi 2019-11-11 /pmc/articles/PMC6878783/ /pubmed/31814873 http://dx.doi.org/10.1155/2019/3849692 Text en Copyright © 2019 Mónika Sztretye et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sztretye, Mónika
Dienes, Beatrix
Gönczi, Mónika
Czirják, Tamás
Csernoch, László
Dux, László
Szentesi, Péter
Keller-Pintér, Anikó
Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging
title Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging
title_full Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging
title_fullStr Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging
title_full_unstemmed Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging
title_short Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging
title_sort astaxanthin: a potential mitochondrial-targeted antioxidant treatment in diseases and with aging
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878783/
https://www.ncbi.nlm.nih.gov/pubmed/31814873
http://dx.doi.org/10.1155/2019/3849692
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