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Solitary Colorectal Cancer Metastasis to the Pancreas

INTRODUCTION: Secondary pancreatic metastasis from other solid organ malignancy is rare and accounts for less than 2% of all pancreatic tumors. The aim of this study is to highlight that colorectal metastatic disease in the pancreas could be in selected cases an indication for surgery rather than fo...

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Autores principales: Karageorgou, M., Myoteri, D., Kotsis, T., Polymeneas, G., Bournakis, E., Dellaportas, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878798/
https://www.ncbi.nlm.nih.gov/pubmed/31815031
http://dx.doi.org/10.1155/2019/4891512
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author Karageorgou, M.
Myoteri, D.
Kotsis, T.
Polymeneas, G.
Bournakis, E.
Dellaportas, D.
author_facet Karageorgou, M.
Myoteri, D.
Kotsis, T.
Polymeneas, G.
Bournakis, E.
Dellaportas, D.
author_sort Karageorgou, M.
collection PubMed
description INTRODUCTION: Secondary pancreatic metastasis from other solid organ malignancy is rare and accounts for less than 2% of all pancreatic tumors. The aim of this study is to highlight that colorectal metastatic disease in the pancreas could be in selected cases an indication for surgery rather than for palliative chemotherapy. CASE PRESENTATION: We present a case of a 62-year-old Caucasian female with a history of rectal adenocarcinoma. Four years ago, the patient underwent low anterior resection of the rectosigmoid, post neoadjuvant chemoradiotherapy, with adjuvant chemotherapy. During her follow-up, imaging examinations revealed a lesion in the pancreatic neck with features indicating primary pancreatic cancer. Near-total distal pancreatectomy with en bloc splenectomy was performed. Histopathology revealed metastatic disease compatible with colorectal adenocarcinoma as the primary cancer. Second-line chemotherapy was decided from the institutional tumor board. The patient remains disease free one year later. CONCLUSION: Pancreatic lesions in patients with a history of extrapancreatic malignancy should raise suspicions of metastatic disease. Surgical intervention is a legitimate treatment option for these pancreatic lesions, since they represent solitary disease deposits and of course in the context of multidisciplinary meeting decisions, and after proper and extensive staging investigations.
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spelling pubmed-68787982019-12-08 Solitary Colorectal Cancer Metastasis to the Pancreas Karageorgou, M. Myoteri, D. Kotsis, T. Polymeneas, G. Bournakis, E. Dellaportas, D. Case Rep Surg Case Report INTRODUCTION: Secondary pancreatic metastasis from other solid organ malignancy is rare and accounts for less than 2% of all pancreatic tumors. The aim of this study is to highlight that colorectal metastatic disease in the pancreas could be in selected cases an indication for surgery rather than for palliative chemotherapy. CASE PRESENTATION: We present a case of a 62-year-old Caucasian female with a history of rectal adenocarcinoma. Four years ago, the patient underwent low anterior resection of the rectosigmoid, post neoadjuvant chemoradiotherapy, with adjuvant chemotherapy. During her follow-up, imaging examinations revealed a lesion in the pancreatic neck with features indicating primary pancreatic cancer. Near-total distal pancreatectomy with en bloc splenectomy was performed. Histopathology revealed metastatic disease compatible with colorectal adenocarcinoma as the primary cancer. Second-line chemotherapy was decided from the institutional tumor board. The patient remains disease free one year later. CONCLUSION: Pancreatic lesions in patients with a history of extrapancreatic malignancy should raise suspicions of metastatic disease. Surgical intervention is a legitimate treatment option for these pancreatic lesions, since they represent solitary disease deposits and of course in the context of multidisciplinary meeting decisions, and after proper and extensive staging investigations. Hindawi 2019-11-07 /pmc/articles/PMC6878798/ /pubmed/31815031 http://dx.doi.org/10.1155/2019/4891512 Text en Copyright © 2019 M. Karageorgou et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Karageorgou, M.
Myoteri, D.
Kotsis, T.
Polymeneas, G.
Bournakis, E.
Dellaportas, D.
Solitary Colorectal Cancer Metastasis to the Pancreas
title Solitary Colorectal Cancer Metastasis to the Pancreas
title_full Solitary Colorectal Cancer Metastasis to the Pancreas
title_fullStr Solitary Colorectal Cancer Metastasis to the Pancreas
title_full_unstemmed Solitary Colorectal Cancer Metastasis to the Pancreas
title_short Solitary Colorectal Cancer Metastasis to the Pancreas
title_sort solitary colorectal cancer metastasis to the pancreas
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878798/
https://www.ncbi.nlm.nih.gov/pubmed/31815031
http://dx.doi.org/10.1155/2019/4891512
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