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The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs
Ischemia-reperfusion (I/R) injury is a common pathological process, which may lead to dysfunctions and failures of multiple organs. A flawless medical way of endogenous therapeutic target can illuminate accurate clinical applications. γ-Aminobutyric acid (GABA) has been known as a marker in I/R inju...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878816/ https://www.ncbi.nlm.nih.gov/pubmed/31814874 http://dx.doi.org/10.1155/2019/4028394 |
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author | Chen, Chaoran Zhou, Xiang He, Jialiang Xie, Zhenxing Xia, Shufang Lu, Guangli |
author_facet | Chen, Chaoran Zhou, Xiang He, Jialiang Xie, Zhenxing Xia, Shufang Lu, Guangli |
author_sort | Chen, Chaoran |
collection | PubMed |
description | Ischemia-reperfusion (I/R) injury is a common pathological process, which may lead to dysfunctions and failures of multiple organs. A flawless medical way of endogenous therapeutic target can illuminate accurate clinical applications. γ-Aminobutyric acid (GABA) has been known as a marker in I/R injury of the central nervous system (mainly in the brain) for a long time, and it may play a vital role in the occurrence of I/R injury. It has been observed that throughout cerebral I/R, levels, syntheses, releases, metabolisms, receptors, and transmissions of GABA undergo complex pathological variations. Scientists have investigated the GABAergic enhancers for attenuating cerebral I/R injury; however, discussions on existing problems and mechanisms of available drugs were seldom carried out so far. Therefore, this review would summarize the process of pathological variations in the GABA system under cerebral I/R injury and will cover corresponding probable issues and mechanisms in using GABA-related drugs to illuminate the concern about clinical illness for accurately preventing cerebral I/R injury. In addition, the study will summarize the increasing GABA signals that can prevent I/R injuries occurring in peripheral organs, and the roles of GABA were also discussed correspondingly. |
format | Online Article Text |
id | pubmed-6878816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-68788162019-12-08 The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs Chen, Chaoran Zhou, Xiang He, Jialiang Xie, Zhenxing Xia, Shufang Lu, Guangli Oxid Med Cell Longev Review Article Ischemia-reperfusion (I/R) injury is a common pathological process, which may lead to dysfunctions and failures of multiple organs. A flawless medical way of endogenous therapeutic target can illuminate accurate clinical applications. γ-Aminobutyric acid (GABA) has been known as a marker in I/R injury of the central nervous system (mainly in the brain) for a long time, and it may play a vital role in the occurrence of I/R injury. It has been observed that throughout cerebral I/R, levels, syntheses, releases, metabolisms, receptors, and transmissions of GABA undergo complex pathological variations. Scientists have investigated the GABAergic enhancers for attenuating cerebral I/R injury; however, discussions on existing problems and mechanisms of available drugs were seldom carried out so far. Therefore, this review would summarize the process of pathological variations in the GABA system under cerebral I/R injury and will cover corresponding probable issues and mechanisms in using GABA-related drugs to illuminate the concern about clinical illness for accurately preventing cerebral I/R injury. In addition, the study will summarize the increasing GABA signals that can prevent I/R injuries occurring in peripheral organs, and the roles of GABA were also discussed correspondingly. Hindawi 2019-11-11 /pmc/articles/PMC6878816/ /pubmed/31814874 http://dx.doi.org/10.1155/2019/4028394 Text en Copyright © 2019 Chaoran Chen et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Chen, Chaoran Zhou, Xiang He, Jialiang Xie, Zhenxing Xia, Shufang Lu, Guangli The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs |
title | The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs |
title_full | The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs |
title_fullStr | The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs |
title_full_unstemmed | The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs |
title_short | The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs |
title_sort | roles of gaba in ischemia-reperfusion injury in the central nervous system and peripheral organs |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878816/ https://www.ncbi.nlm.nih.gov/pubmed/31814874 http://dx.doi.org/10.1155/2019/4028394 |
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