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The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs

Ischemia-reperfusion (I/R) injury is a common pathological process, which may lead to dysfunctions and failures of multiple organs. A flawless medical way of endogenous therapeutic target can illuminate accurate clinical applications. γ-Aminobutyric acid (GABA) has been known as a marker in I/R inju...

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Autores principales: Chen, Chaoran, Zhou, Xiang, He, Jialiang, Xie, Zhenxing, Xia, Shufang, Lu, Guangli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878816/
https://www.ncbi.nlm.nih.gov/pubmed/31814874
http://dx.doi.org/10.1155/2019/4028394
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author Chen, Chaoran
Zhou, Xiang
He, Jialiang
Xie, Zhenxing
Xia, Shufang
Lu, Guangli
author_facet Chen, Chaoran
Zhou, Xiang
He, Jialiang
Xie, Zhenxing
Xia, Shufang
Lu, Guangli
author_sort Chen, Chaoran
collection PubMed
description Ischemia-reperfusion (I/R) injury is a common pathological process, which may lead to dysfunctions and failures of multiple organs. A flawless medical way of endogenous therapeutic target can illuminate accurate clinical applications. γ-Aminobutyric acid (GABA) has been known as a marker in I/R injury of the central nervous system (mainly in the brain) for a long time, and it may play a vital role in the occurrence of I/R injury. It has been observed that throughout cerebral I/R, levels, syntheses, releases, metabolisms, receptors, and transmissions of GABA undergo complex pathological variations. Scientists have investigated the GABAergic enhancers for attenuating cerebral I/R injury; however, discussions on existing problems and mechanisms of available drugs were seldom carried out so far. Therefore, this review would summarize the process of pathological variations in the GABA system under cerebral I/R injury and will cover corresponding probable issues and mechanisms in using GABA-related drugs to illuminate the concern about clinical illness for accurately preventing cerebral I/R injury. In addition, the study will summarize the increasing GABA signals that can prevent I/R injuries occurring in peripheral organs, and the roles of GABA were also discussed correspondingly.
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spelling pubmed-68788162019-12-08 The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs Chen, Chaoran Zhou, Xiang He, Jialiang Xie, Zhenxing Xia, Shufang Lu, Guangli Oxid Med Cell Longev Review Article Ischemia-reperfusion (I/R) injury is a common pathological process, which may lead to dysfunctions and failures of multiple organs. A flawless medical way of endogenous therapeutic target can illuminate accurate clinical applications. γ-Aminobutyric acid (GABA) has been known as a marker in I/R injury of the central nervous system (mainly in the brain) for a long time, and it may play a vital role in the occurrence of I/R injury. It has been observed that throughout cerebral I/R, levels, syntheses, releases, metabolisms, receptors, and transmissions of GABA undergo complex pathological variations. Scientists have investigated the GABAergic enhancers for attenuating cerebral I/R injury; however, discussions on existing problems and mechanisms of available drugs were seldom carried out so far. Therefore, this review would summarize the process of pathological variations in the GABA system under cerebral I/R injury and will cover corresponding probable issues and mechanisms in using GABA-related drugs to illuminate the concern about clinical illness for accurately preventing cerebral I/R injury. In addition, the study will summarize the increasing GABA signals that can prevent I/R injuries occurring in peripheral organs, and the roles of GABA were also discussed correspondingly. Hindawi 2019-11-11 /pmc/articles/PMC6878816/ /pubmed/31814874 http://dx.doi.org/10.1155/2019/4028394 Text en Copyright © 2019 Chaoran Chen et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chen, Chaoran
Zhou, Xiang
He, Jialiang
Xie, Zhenxing
Xia, Shufang
Lu, Guangli
The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs
title The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs
title_full The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs
title_fullStr The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs
title_full_unstemmed The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs
title_short The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs
title_sort roles of gaba in ischemia-reperfusion injury in the central nervous system and peripheral organs
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878816/
https://www.ncbi.nlm.nih.gov/pubmed/31814874
http://dx.doi.org/10.1155/2019/4028394
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