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Effect of brachial-ankle pulse wave velocity combined with blood pressure on cardio-cerebrovascular events

The aim of the present study was to evaluate the effect of brachial-ankle pulse wave velocity (baPWV) combined with blood pressure (BP) on cardio-cerebrovascular events. Participants who received health examinations during the periods 2010–2011, 2012–2013 and 2014–2015 were recruited. The participan...

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Autores principales: Wu, Yuntao, Zhang, Yajing, Gao, Jingsheng, Man, Shuli, Xing, Jianong, Cao, Zhiwei, Song, Shaomin, Wu, Shouling, Gao, Wenyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878894/
https://www.ncbi.nlm.nih.gov/pubmed/31807146
http://dx.doi.org/10.3892/etm.2019.8149
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author Wu, Yuntao
Zhang, Yajing
Gao, Jingsheng
Man, Shuli
Xing, Jianong
Cao, Zhiwei
Song, Shaomin
Wu, Shouling
Gao, Wenyuan
author_facet Wu, Yuntao
Zhang, Yajing
Gao, Jingsheng
Man, Shuli
Xing, Jianong
Cao, Zhiwei
Song, Shaomin
Wu, Shouling
Gao, Wenyuan
author_sort Wu, Yuntao
collection PubMed
description The aim of the present study was to evaluate the effect of brachial-ankle pulse wave velocity (baPWV) combined with blood pressure (BP) on cardio-cerebrovascular events. Participants who received health examinations during the periods 2010–2011, 2012–2013 and 2014–2015 were recruited. The participants were divided into four groups according to their BP and baPWV levels as follows: Normotension + low baPWV, normotension + high baPWV, hypertension + low baPWV, and hypertension + high baPWV. The cumulative incidence of cardio-cerebrovascular events was calculated using life-table analysis, and the associations of BP and baPWV with cardio-cerebrovascular events were analyzed using a multivariate Cox proportional hazards regression model. Receiver operating characteristic curves were used to calculate the predictive values of baPWV combined with BP, baPWV alone or BP alone for cardio-cerebrovascular events by comparing their area under the curve (AUC) using the normal approximation method. There were 20,310 participants with a mean age of 50.13±0.09 years in the present study, including 13,240 males. A total of 278 participants developed a cardio-cerebrovascular event after a mean follow-up period of 3.34±1.82 years. The cumulative incidence of cardio-cerebrovascular events in the normotension + low baPWV, normotension + high baPWV, hypertension + low baPWV and hypertension + high baPWV groups was 0.2, 0.9, 0.8 and 3.1%. Multivariate Cox proportional hazards regression analysis showed that compared with the normotension + low baPWV group, the risks of cardio-cerebrovascular events in the normotension + high baPWV, hypertension + low baPWV and hypertension + high baPWV groups were increased after adjusting for confounding factors, and their hazard ratios (95% CI) were 4.18 (2.23–7.83), 3.00 (1.39–6.47) and 9.34 (5.14–16.96), respectively. The AUC values for the predictive values of baPWV combined with BP, baPWV alone and BP alone on cardio-cerebrovascular events were calculated to be 0.744, 0.677 and 0.698, respectively. In conclusion, high baPWV accompanied by hypertension could increase the risk of cardio-cerebrovascular events. The predictive value of baPWV combined with BP on cardio-cerebrovascular events is superior compared with that of either baPWV or BP alone.
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spelling pubmed-68788942019-12-05 Effect of brachial-ankle pulse wave velocity combined with blood pressure on cardio-cerebrovascular events Wu, Yuntao Zhang, Yajing Gao, Jingsheng Man, Shuli Xing, Jianong Cao, Zhiwei Song, Shaomin Wu, Shouling Gao, Wenyuan Exp Ther Med Articles The aim of the present study was to evaluate the effect of brachial-ankle pulse wave velocity (baPWV) combined with blood pressure (BP) on cardio-cerebrovascular events. Participants who received health examinations during the periods 2010–2011, 2012–2013 and 2014–2015 were recruited. The participants were divided into four groups according to their BP and baPWV levels as follows: Normotension + low baPWV, normotension + high baPWV, hypertension + low baPWV, and hypertension + high baPWV. The cumulative incidence of cardio-cerebrovascular events was calculated using life-table analysis, and the associations of BP and baPWV with cardio-cerebrovascular events were analyzed using a multivariate Cox proportional hazards regression model. Receiver operating characteristic curves were used to calculate the predictive values of baPWV combined with BP, baPWV alone or BP alone for cardio-cerebrovascular events by comparing their area under the curve (AUC) using the normal approximation method. There were 20,310 participants with a mean age of 50.13±0.09 years in the present study, including 13,240 males. A total of 278 participants developed a cardio-cerebrovascular event after a mean follow-up period of 3.34±1.82 years. The cumulative incidence of cardio-cerebrovascular events in the normotension + low baPWV, normotension + high baPWV, hypertension + low baPWV and hypertension + high baPWV groups was 0.2, 0.9, 0.8 and 3.1%. Multivariate Cox proportional hazards regression analysis showed that compared with the normotension + low baPWV group, the risks of cardio-cerebrovascular events in the normotension + high baPWV, hypertension + low baPWV and hypertension + high baPWV groups were increased after adjusting for confounding factors, and their hazard ratios (95% CI) were 4.18 (2.23–7.83), 3.00 (1.39–6.47) and 9.34 (5.14–16.96), respectively. The AUC values for the predictive values of baPWV combined with BP, baPWV alone and BP alone on cardio-cerebrovascular events were calculated to be 0.744, 0.677 and 0.698, respectively. In conclusion, high baPWV accompanied by hypertension could increase the risk of cardio-cerebrovascular events. The predictive value of baPWV combined with BP on cardio-cerebrovascular events is superior compared with that of either baPWV or BP alone. D.A. Spandidos 2019-12 2019-10-30 /pmc/articles/PMC6878894/ /pubmed/31807146 http://dx.doi.org/10.3892/etm.2019.8149 Text en Copyright: © Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Wu, Yuntao
Zhang, Yajing
Gao, Jingsheng
Man, Shuli
Xing, Jianong
Cao, Zhiwei
Song, Shaomin
Wu, Shouling
Gao, Wenyuan
Effect of brachial-ankle pulse wave velocity combined with blood pressure on cardio-cerebrovascular events
title Effect of brachial-ankle pulse wave velocity combined with blood pressure on cardio-cerebrovascular events
title_full Effect of brachial-ankle pulse wave velocity combined with blood pressure on cardio-cerebrovascular events
title_fullStr Effect of brachial-ankle pulse wave velocity combined with blood pressure on cardio-cerebrovascular events
title_full_unstemmed Effect of brachial-ankle pulse wave velocity combined with blood pressure on cardio-cerebrovascular events
title_short Effect of brachial-ankle pulse wave velocity combined with blood pressure on cardio-cerebrovascular events
title_sort effect of brachial-ankle pulse wave velocity combined with blood pressure on cardio-cerebrovascular events
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878894/
https://www.ncbi.nlm.nih.gov/pubmed/31807146
http://dx.doi.org/10.3892/etm.2019.8149
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