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Epigenomics of Pancreatic Cancer: A Critical Role for Epigenome-Wide Studies
Several challenges present themselves when discussing current approaches to the prevention or treatment of pancreatic cancer. Up to 45% of the risk of pancreatic cancer is attributed to unknown causes, making effective prevention programs difficult to design. The most common type of pancreatic cance...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879055/ https://www.ncbi.nlm.nih.gov/pubmed/31772762 http://dx.doi.org/10.3390/epigenomes3010005 |
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author | Singh, Rahul R. Reindl, Katie M. Jansen, Rick J. |
author_facet | Singh, Rahul R. Reindl, Katie M. Jansen, Rick J. |
author_sort | Singh, Rahul R. |
collection | PubMed |
description | Several challenges present themselves when discussing current approaches to the prevention or treatment of pancreatic cancer. Up to 45% of the risk of pancreatic cancer is attributed to unknown causes, making effective prevention programs difficult to design. The most common type of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC), is generally diagnosed at a late stage, leading to a poor prognosis and 5-year survival estimate. PDAC tumors are heterogeneous, leading to many identified cell subtypes within one patient’s primary tumor. This explains why there is a high frequency of tumors that are resistant to standard treatments, leading to high relapse rates. This review will discuss how epigenetic technologies and epigenome-wide association studies have been used to address some of these challenges and the future promises these approaches hold. |
format | Online Article Text |
id | pubmed-6879055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68790552019-11-26 Epigenomics of Pancreatic Cancer: A Critical Role for Epigenome-Wide Studies Singh, Rahul R. Reindl, Katie M. Jansen, Rick J. Epigenomes Review Several challenges present themselves when discussing current approaches to the prevention or treatment of pancreatic cancer. Up to 45% of the risk of pancreatic cancer is attributed to unknown causes, making effective prevention programs difficult to design. The most common type of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC), is generally diagnosed at a late stage, leading to a poor prognosis and 5-year survival estimate. PDAC tumors are heterogeneous, leading to many identified cell subtypes within one patient’s primary tumor. This explains why there is a high frequency of tumors that are resistant to standard treatments, leading to high relapse rates. This review will discuss how epigenetic technologies and epigenome-wide association studies have been used to address some of these challenges and the future promises these approaches hold. MDPI 2019-01-19 /pmc/articles/PMC6879055/ /pubmed/31772762 http://dx.doi.org/10.3390/epigenomes3010005 Text en © 2019 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Review Singh, Rahul R. Reindl, Katie M. Jansen, Rick J. Epigenomics of Pancreatic Cancer: A Critical Role for Epigenome-Wide Studies |
title | Epigenomics of Pancreatic Cancer: A Critical Role for Epigenome-Wide Studies |
title_full | Epigenomics of Pancreatic Cancer: A Critical Role for Epigenome-Wide Studies |
title_fullStr | Epigenomics of Pancreatic Cancer: A Critical Role for Epigenome-Wide Studies |
title_full_unstemmed | Epigenomics of Pancreatic Cancer: A Critical Role for Epigenome-Wide Studies |
title_short | Epigenomics of Pancreatic Cancer: A Critical Role for Epigenome-Wide Studies |
title_sort | epigenomics of pancreatic cancer: a critical role for epigenome-wide studies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879055/ https://www.ncbi.nlm.nih.gov/pubmed/31772762 http://dx.doi.org/10.3390/epigenomes3010005 |
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