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Epigenomics of Pancreatic Cancer: A Critical Role for Epigenome-Wide Studies

Several challenges present themselves when discussing current approaches to the prevention or treatment of pancreatic cancer. Up to 45% of the risk of pancreatic cancer is attributed to unknown causes, making effective prevention programs difficult to design. The most common type of pancreatic cance...

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Detalles Bibliográficos
Autores principales: Singh, Rahul R., Reindl, Katie M., Jansen, Rick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879055/
https://www.ncbi.nlm.nih.gov/pubmed/31772762
http://dx.doi.org/10.3390/epigenomes3010005
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author Singh, Rahul R.
Reindl, Katie M.
Jansen, Rick J.
author_facet Singh, Rahul R.
Reindl, Katie M.
Jansen, Rick J.
author_sort Singh, Rahul R.
collection PubMed
description Several challenges present themselves when discussing current approaches to the prevention or treatment of pancreatic cancer. Up to 45% of the risk of pancreatic cancer is attributed to unknown causes, making effective prevention programs difficult to design. The most common type of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC), is generally diagnosed at a late stage, leading to a poor prognosis and 5-year survival estimate. PDAC tumors are heterogeneous, leading to many identified cell subtypes within one patient’s primary tumor. This explains why there is a high frequency of tumors that are resistant to standard treatments, leading to high relapse rates. This review will discuss how epigenetic technologies and epigenome-wide association studies have been used to address some of these challenges and the future promises these approaches hold.
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spelling pubmed-68790552019-11-26 Epigenomics of Pancreatic Cancer: A Critical Role for Epigenome-Wide Studies Singh, Rahul R. Reindl, Katie M. Jansen, Rick J. Epigenomes Review Several challenges present themselves when discussing current approaches to the prevention or treatment of pancreatic cancer. Up to 45% of the risk of pancreatic cancer is attributed to unknown causes, making effective prevention programs difficult to design. The most common type of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC), is generally diagnosed at a late stage, leading to a poor prognosis and 5-year survival estimate. PDAC tumors are heterogeneous, leading to many identified cell subtypes within one patient’s primary tumor. This explains why there is a high frequency of tumors that are resistant to standard treatments, leading to high relapse rates. This review will discuss how epigenetic technologies and epigenome-wide association studies have been used to address some of these challenges and the future promises these approaches hold. MDPI 2019-01-19 /pmc/articles/PMC6879055/ /pubmed/31772762 http://dx.doi.org/10.3390/epigenomes3010005 Text en © 2019 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Singh, Rahul R.
Reindl, Katie M.
Jansen, Rick J.
Epigenomics of Pancreatic Cancer: A Critical Role for Epigenome-Wide Studies
title Epigenomics of Pancreatic Cancer: A Critical Role for Epigenome-Wide Studies
title_full Epigenomics of Pancreatic Cancer: A Critical Role for Epigenome-Wide Studies
title_fullStr Epigenomics of Pancreatic Cancer: A Critical Role for Epigenome-Wide Studies
title_full_unstemmed Epigenomics of Pancreatic Cancer: A Critical Role for Epigenome-Wide Studies
title_short Epigenomics of Pancreatic Cancer: A Critical Role for Epigenome-Wide Studies
title_sort epigenomics of pancreatic cancer: a critical role for epigenome-wide studies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879055/
https://www.ncbi.nlm.nih.gov/pubmed/31772762
http://dx.doi.org/10.3390/epigenomes3010005
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