Clade F AAVHSCs cross the blood brain barrier and transduce the central nervous system in addition to peripheral tissues following intravenous administration in nonhuman primates

The biodistribution of AAVHSC7, AAVHSC15, and AAVHSC17 following systemic delivery was assessed in cynomolgus macaques (Macaca fascicularis). Animals received a single intravenous (IV) injection of a self-complementary AAVHSC-enhanced green fluorescent protein (eGFP) vector and tissues were harveste...

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Detalles Bibliográficos
Autores principales: Ellsworth, Jeff L., Gingras, Jacinthe, Smith, Laura J., Rubin, Hillard, Seabrook, Tania A., Patel, Kruti, Zapata, Nicole, Olivieri, Kevin, O’Callaghan, Michael, Chlipala, Elizabeth, Morales, Pablo, Seymour, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879147/
https://www.ncbi.nlm.nih.gov/pubmed/31770409
http://dx.doi.org/10.1371/journal.pone.0225582

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