Comprehensive Genome Analysis of Carbapenem-Resistant Strains of Raoultella Species, an Emerging Multidrug-Resistant Bacterium in Hospitals

We report the characterization of six carbapenem-resistant Raoultella spp. (CRRS) in our hospital and a genomic analysis of 58 publicly available isolates. CRRS isolates are sporadically identified around the world, and different transposons carrying carbapenemases were the resistant mechanisms. Mob...

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Autores principales: Yu, Xiao, Zheng, Beiwen, Zhang, Jing, Xu, Hao, Xiao, Tingting, Zhou, Yanzi, Zhang, Shuntian, Zhu, Yunying, Wang, Yuan, Xiao, Yonghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879265/
https://www.ncbi.nlm.nih.gov/pubmed/31570399
http://dx.doi.org/10.1128/AAC.01367-19
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author Yu, Xiao
Zheng, Beiwen
Zhang, Jing
Xu, Hao
Xiao, Tingting
Zhou, Yanzi
Zhang, Shuntian
Zhu, Yunying
Wang, Yuan
Xiao, Yonghong
author_facet Yu, Xiao
Zheng, Beiwen
Zhang, Jing
Xu, Hao
Xiao, Tingting
Zhou, Yanzi
Zhang, Shuntian
Zhu, Yunying
Wang, Yuan
Xiao, Yonghong
author_sort Yu, Xiao
collection PubMed
description We report the characterization of six carbapenem-resistant Raoultella spp. (CRRS) in our hospital and a genomic analysis of 58 publicly available isolates. CRRS isolates are sporadically identified around the world, and different transposons carrying carbapenemases were the resistant mechanisms. Mobile genetic elements play an important role in acquiring antibiotic resistance genes from the hospital. An improved understanding of these transposon and targeted control measures will be very valuable to prevent CRRS dissemination.
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spelling pubmed-68792652019-12-03 Comprehensive Genome Analysis of Carbapenem-Resistant Strains of Raoultella Species, an Emerging Multidrug-Resistant Bacterium in Hospitals Yu, Xiao Zheng, Beiwen Zhang, Jing Xu, Hao Xiao, Tingting Zhou, Yanzi Zhang, Shuntian Zhu, Yunying Wang, Yuan Xiao, Yonghong Antimicrob Agents Chemother Mechanisms of Resistance We report the characterization of six carbapenem-resistant Raoultella spp. (CRRS) in our hospital and a genomic analysis of 58 publicly available isolates. CRRS isolates are sporadically identified around the world, and different transposons carrying carbapenemases were the resistant mechanisms. Mobile genetic elements play an important role in acquiring antibiotic resistance genes from the hospital. An improved understanding of these transposon and targeted control measures will be very valuable to prevent CRRS dissemination. American Society for Microbiology 2019-11-21 /pmc/articles/PMC6879265/ /pubmed/31570399 http://dx.doi.org/10.1128/AAC.01367-19 Text en Copyright © 2019 Yu et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Mechanisms of Resistance
Yu, Xiao
Zheng, Beiwen
Zhang, Jing
Xu, Hao
Xiao, Tingting
Zhou, Yanzi
Zhang, Shuntian
Zhu, Yunying
Wang, Yuan
Xiao, Yonghong
Comprehensive Genome Analysis of Carbapenem-Resistant Strains of Raoultella Species, an Emerging Multidrug-Resistant Bacterium in Hospitals
title Comprehensive Genome Analysis of Carbapenem-Resistant Strains of Raoultella Species, an Emerging Multidrug-Resistant Bacterium in Hospitals
title_full Comprehensive Genome Analysis of Carbapenem-Resistant Strains of Raoultella Species, an Emerging Multidrug-Resistant Bacterium in Hospitals
title_fullStr Comprehensive Genome Analysis of Carbapenem-Resistant Strains of Raoultella Species, an Emerging Multidrug-Resistant Bacterium in Hospitals
title_full_unstemmed Comprehensive Genome Analysis of Carbapenem-Resistant Strains of Raoultella Species, an Emerging Multidrug-Resistant Bacterium in Hospitals
title_short Comprehensive Genome Analysis of Carbapenem-Resistant Strains of Raoultella Species, an Emerging Multidrug-Resistant Bacterium in Hospitals
title_sort comprehensive genome analysis of carbapenem-resistant strains of raoultella species, an emerging multidrug-resistant bacterium in hospitals
topic Mechanisms of Resistance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879265/
https://www.ncbi.nlm.nih.gov/pubmed/31570399
http://dx.doi.org/10.1128/AAC.01367-19
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