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Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin β

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by abnormal deposition of β-amyloid (Aβ) peptides. Aβ is a cleavage product of the amyloid precursor protein (APP), and aberrant posttranslational modifications of APP can alter APP processing and increase Aβ generation. In...

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Detalles Bibliográficos
Autores principales:	Menon, Preeti Kumaran, Koistinen, Niina Anneli, Iverfeldt, Kerstin, Ström, Anna-Lena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2019
Materias:	Neurobiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879340/ https://www.ncbi.nlm.nih.gov/pubmed/31604820 http://dx.doi.org/10.1074/jbc.RA119.008310

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