Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment

A Sr-based metal-organic framework (MOF) is introduced as ketoprofen carrier to form a comprehensive system for treating osteoarthritis (OA), and the drug loading amount and release rate is investigated. Structural characterization of the samples showed that Sr/PTA-MOF had good crystal morphology an...

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Autores principales: Li, Zhen, Peng, Ying, Xia, Xingyu, Cao, Zhe, Deng, Yuqing, Tang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879484/
https://www.ncbi.nlm.nih.gov/pubmed/31772254
http://dx.doi.org/10.1038/s41598-019-54147-5
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author Li, Zhen
Peng, Ying
Xia, Xingyu
Cao, Zhe
Deng, Yuqing
Tang, Bin
author_facet Li, Zhen
Peng, Ying
Xia, Xingyu
Cao, Zhe
Deng, Yuqing
Tang, Bin
author_sort Li, Zhen
collection PubMed
description A Sr-based metal-organic framework (MOF) is introduced as ketoprofen carrier to form a comprehensive system for treating osteoarthritis (OA), and the drug loading amount and release rate is investigated. Structural characterization of the samples showed that Sr/PTA-MOF had good crystal morphology and structure, and chemical and thermal stability. Ketoprofen was successfully loaded on the MOF carrier, which had been identified by high performance liquid chromatography (HPLC) and thermogravimetric analysis (TGA). The release experiment manifested that more than 90% of ketoprofen released from Sr/PTA-MOF after 24 h, and ketoprofen delivery was mainly governed by the Higuchi model. Furthermore, cytotoxicity experiment manifested that synthesized MOF carrier had no poisonous effect on OA chondrocytes, which provided a preliminary foundation for the realization of comprehensive treating OA.
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spelling pubmed-68794842019-12-05 Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment Li, Zhen Peng, Ying Xia, Xingyu Cao, Zhe Deng, Yuqing Tang, Bin Sci Rep Article A Sr-based metal-organic framework (MOF) is introduced as ketoprofen carrier to form a comprehensive system for treating osteoarthritis (OA), and the drug loading amount and release rate is investigated. Structural characterization of the samples showed that Sr/PTA-MOF had good crystal morphology and structure, and chemical and thermal stability. Ketoprofen was successfully loaded on the MOF carrier, which had been identified by high performance liquid chromatography (HPLC) and thermogravimetric analysis (TGA). The release experiment manifested that more than 90% of ketoprofen released from Sr/PTA-MOF after 24 h, and ketoprofen delivery was mainly governed by the Higuchi model. Furthermore, cytotoxicity experiment manifested that synthesized MOF carrier had no poisonous effect on OA chondrocytes, which provided a preliminary foundation for the realization of comprehensive treating OA. Nature Publishing Group UK 2019-11-26 /pmc/articles/PMC6879484/ /pubmed/31772254 http://dx.doi.org/10.1038/s41598-019-54147-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Li, Zhen
Peng, Ying
Xia, Xingyu
Cao, Zhe
Deng, Yuqing
Tang, Bin
Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment
title Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment
title_full Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment
title_fullStr Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment
title_full_unstemmed Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment
title_short Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment
title_sort sr/pta metal organic framework as a drug delivery system for osteoarthritis treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879484/
https://www.ncbi.nlm.nih.gov/pubmed/31772254
http://dx.doi.org/10.1038/s41598-019-54147-5
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