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Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases

Pif1 plays multiple roles in maintaining genome stability and preferentially unwinds forked dsDNA, but the mechanism by which Pif1 unwinds forked dsDNA remains elusive. Here we report the structure of Bacteroides sp Pif1 (BaPif1) in complex with a symmetrical double forked dsDNA. Two interacting BaP...

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Detalles Bibliográficos
Autores principales:	Su, Nannan, Byrd, Alicia K., Bharath, Sakshibeedu R., Yang, Olivia, Jia, Yu, Tang, Xuhua, Ha, Taekjip, Raney, Kevin D., Song, Haiwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879534/ https://www.ncbi.nlm.nih.gov/pubmed/31772234 http://dx.doi.org/10.1038/s41467-019-13414-9

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