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Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling

Potassium channels are presumed to have two allosterically coupled gates, the activation gate and the selectivity filter gate, that control channel opening, closing, and inactivation. However, the molecular mechanism of how these gates regulate K(+ )ion flow through the channel remains poorly unders...

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Detalles Bibliográficos
Autores principales: Kopec, Wojciech, Rothberg, Brad S., de Groot, Bert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879586/
https://www.ncbi.nlm.nih.gov/pubmed/31772184
http://dx.doi.org/10.1038/s41467-019-13227-w