Cargando…

The fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma

Glioblastoma Multiforme (GBM) is the most common and aggressive primary brain tumor. Despite recent developments in surgery, chemo- and radio-therapy, a currently poor prognosis of GBM patients highlights an urgent need for novel treatment strategies. TRAIL (TNF Related Apoptosis Inducing Ligand) is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ozyerli-Goknar, Ezgi, Sur-Erdem, Ilknur, Seker, Fidan, Cingöz, Ahmet, Kayabolen, Alisan, Kahya-Yesil, Zeynep, Uyulur, Fırat, Gezen, Melike, Tolay, Nazife, Erman, Batu, Gönen, Mehmet, Dunford, James, Oppermann, Udo, Bagci-Onder, Tugba
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879621/ https://www.ncbi.nlm.nih.gov/pubmed/31772153 http://dx.doi.org/10.1038/s41419-019-2107-y

Ejemplares similares

Epigenetic Deregulation of Apoptosis in Cancers
por: Ozyerli-Goknar, Ezgi, et al.
Publicado: (2021)

The pro-apoptotic Bcl-2 family member Harakiri (HRK) induces cell death in glioblastoma multiforme
por: Kaya-Aksoy, Ezgi, et al.
Publicado: (2019)

DDRE-03. IDH1-MUTANT GBM CELLS ARE HIGHLY SENSITIVE TO COMBINATION OF KDM6A/B AND HDAC INHIBITORS
por: Kayabölen, Alişan, et al.
Publicado: (2021)

Identification of SERPINE1 as a Regulator of Glioblastoma Cell Dispersal with Transcriptome Profiling
por: Seker, Fidan, et al.
Publicado: (2019)

IDH Mutations in Glioma: Double-Edged Sword in Clinical Applications?
por: Kayabolen, Alisan, et al.
Publicado: (2021)

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival
por: Ozyerli-Goknar, Ezgi, et al.
Publicado: (2023)

EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities
por: Yedier-Bayram, Ozlem, et al.
Publicado: (2022)

Doxorubicin inhibits miR-140 expression and upregulates PD-L1 expression in HCT116 cells, opposite to its effects on MDA-MB-231 cells
por: NABA, Noel Mopouguini, et al.
Publicado: (2020)

KDM2B, an H3K36-specific demethylase, regulates apoptotic response of GBM cells to TRAIL
por: Kurt, Ibrahim Cagri, et al.
Publicado: (2017)

Sibling rivalry among the ZBTB transcription factor family: homodimers versus heterodimers
por: Piepoli, Sofia, et al.
Publicado: (2022)

Drug Repositioning Screen on a New Primary Cell Line Identifies Potent Therapeutics for Glioblastoma
por: Senbabaoglu, Filiz, et al.
Publicado: (2020)

Tumor Cell Infiltration into the Brain in Glioblastoma: From Mechanisms to Clinical Perspectives
por: Seker-Polat, Fidan, et al.
Publicado: (2022)

A Box of Chemistry to Inhibit the MEN1 Tumor Suppressor Gene Promoting Leukemia
por: Ozyerli‐Goknar, Ezgi, et al.
Publicado: (2021)

Comparative profiling of stress granule clearance reveals differential contributions of the ubiquitin system
por: Tolay, Nazife, et al.
Publicado: (2021)

Role of the Ubiquitin System in Stress Granule Metabolism
por: Tolay, Nazife, et al.
Publicado: (2022)

The anticancer effect of chaetocin is enhanced by inhibition of autophagy
por: Jung, H-J, et al.
Publicado: (2016)

Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer
por: Saraç, Hilal, et al.
Publicado: (2019)

Effect of chaetocin on renal cell carcinoma cells and cytokine-induced killer cells
por: Rombo, Roman, et al.
Publicado: (2016)

Chaetocin Improves Pig Cloning Efficiency by Enhancing Epigenetic Reprogramming and Autophagic Activity
por: Jeong, Pil-Soo, et al.
Publicado: (2020)

Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90
por: Song, Xiaoping, et al.
Publicado: (2015)

Identification of Chaetocin as a Potent non-ROS-mediated Anticancer Drug Candidate for Gastric Cancer
por: Liao, Xinwen, et al.
Publicado: (2019)

Chaetocin exhibits anticancer effects in esophageal squamous cell carcinoma via activation of Hippo pathway
por: Li, Lin, et al.
Publicado: (2023)

LBODP106 Multi-omics Analyses Of MEN1 Missense Mutations Identify Disruption Of Menin-MLL And Menin-JunD Interactions As Critical Requirements For Molecular Pathogenicity
por: Dreijerink, Koen Marie Anton, et al.
Publicado: (2022)

The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation
por: Isham, C R, et al.
Publicado: (2012)

Chaetocin induces caspase-dependent apoptosis in ovarian cancer cells via the generation of reactive oxygen species
por: Li, Zhongjun, et al.
Publicado: (2019)

Chaetocin Promotes Osteogenic Differentiation via Modulating Wnt/Beta-Catenin Signaling in Mesenchymal Stem Cells
por: Liang, Youde, et al.
Publicado: (2021)

Protein Scaffold‐Based Multimerization of Soluble ACE2 Efficiently Blocks SARS‐CoV‐2 Infection In Vitro and In Vivo
por: Kayabolen, Alisan, et al.
Publicado: (2022)

Editorial: Cell Death and Targeted Cancer Therapies
por: Bagci-Onder, Tugba, et al.
Publicado: (2022)

Classification of BCI Users Based on Cognition
por: Ozkan, N. Firat, et al.
Publicado: (2018)

Chaetocin-induced ROS-mediated apoptosis involves ATM–YAP1 axis and JNK-dependent inhibition of glucose metabolism
por: Dixit, D, et al.
Publicado: (2014)

Chaetocin enhances dendritic cell function via the induction of heat shock protein and cancer testis antigens in myeloma cells
por: Vo, Manh-Cuong, et al.
Publicado: (2017)

ROS/JNK/C-Jun Pathway is Involved in Chaetocin Induced Colorectal Cancer Cells Apoptosis and Macrophage Phagocytosis Enhancement
por: Wang, Huihui, et al.
Publicado: (2021)

Multi-omics analyses of MEN1 missense mutations identify disruption of menin–MLL and menin–JunD interactions as critical requirements for molecular pathogenicity
por: Dreijerink, Koen M. A., et al.
Publicado: (2022)

Evaluating the Effect of Therapeutic Stem Cells on TRAIL Resistant and Sensitive Medulloblastomas
por: Nesterenko, Irina, et al.
Publicado: (2012)

Improved Therapeutic Effect against Leukemia by a Combination of the Histone Methyltransferase Inhibitor Chaetocin and the Histone Deacetylase Inhibitor Trichostatin A
por: Tran, Huong Thi Thanh, et al.
Publicado: (2013)

Combined Chaetocin/Trichostatin A Treatment Improves the Epigenetic Modification and Developmental Competence of Porcine Somatic Cell Nuclear Transfer Embryos
por: Jeong, Pil-Soo, et al.
Publicado: (2021)

The neutralization effect of montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies
por: Durdagi, Serdar, et al.
Publicado: (2022)

Neutrophil-mediated Thrombosis and NETosis in Behçet's Disease: a Hypothesis
por: Batu, Ezgi Deniz
Publicado: (2020)

Chaetocin antileukemia activity against chronic myelogenous leukemia cells is potentiated by bone marrow stromal factors and overcomes innate imatinib resistance
por: Truitt, L, et al.
Publicado: (2014)

ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin
por: Wen, Chuangyu, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_b6h2msje88bgb5192s6uft23ho