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Trends of Opioid Utilisation in Denmark: A Nationwide Study
BACKGROUND: Opioid use has more than doubled over recent decades, and Denmark occupies fifth place in the global ranking. These increases have been partly attributed to the ageing population. OBJECTIVE: Our objective was to assess the impact of age over time on utilisation of the most commonly used...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879688/ https://www.ncbi.nlm.nih.gov/pubmed/31535353 http://dx.doi.org/10.1007/s40801-019-00163-w |
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author | Nissen, Søren Kabell Pottegård, Anton Ryg, Jesper |
author_facet | Nissen, Søren Kabell Pottegård, Anton Ryg, Jesper |
author_sort | Nissen, Søren Kabell |
collection | PubMed |
description | BACKGROUND: Opioid use has more than doubled over recent decades, and Denmark occupies fifth place in the global ranking. These increases have been partly attributed to the ageing population. OBJECTIVE: Our objective was to assess the impact of age over time on utilisation of the most commonly used opioids in Denmark. METHODS: We retrieved nationwide sales data on opioid sales in Denmark from 1999 to 2017. We investigated utilisation trends in age groups for the four opioids with the highest use. We used three volume-based metrics (defined daily doses/1000/day, oral morphine equivalents/1000/day, and packages dispensed/year) and one person-based metric (users/1000/year). RESULTS: The four opioids selected according to users/1000/year were tramadol (46.1), codeine and combination products (12.4 for codeine, 3.7 for codeine and acetylsalicylic acid, and 4.2 for codeine and paracetamol), morphine (17.0), and oxycodone (12.1). Overall utilisation according to volume and person metrics increased for all except codeine and combination products. Tramadol doses or strength increased, albeit less with increasing age. Oxycodone doses or strength decreased for all age groups but were nearly unchanged for the age group ≥ 80 years. CONCLUSION: Tramadol is the most utilised opioid in Denmark and was prescribed at increasing doses or strengths over the study period, particularly in the younger (< 80 years) age groups. Overall, oxycodone was prescribed at decreasing doses or strengths over time but remained unchanged for the age group ≥ 80 years. There is a need to address the pharmacological treatment of pain in terms of age, with tramadol and oxycodone being possible targets for regulatory efforts. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s40801-019-00163-w) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6879688 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-68796882019-12-10 Trends of Opioid Utilisation in Denmark: A Nationwide Study Nissen, Søren Kabell Pottegård, Anton Ryg, Jesper Drugs Real World Outcomes Original Research Article BACKGROUND: Opioid use has more than doubled over recent decades, and Denmark occupies fifth place in the global ranking. These increases have been partly attributed to the ageing population. OBJECTIVE: Our objective was to assess the impact of age over time on utilisation of the most commonly used opioids in Denmark. METHODS: We retrieved nationwide sales data on opioid sales in Denmark from 1999 to 2017. We investigated utilisation trends in age groups for the four opioids with the highest use. We used three volume-based metrics (defined daily doses/1000/day, oral morphine equivalents/1000/day, and packages dispensed/year) and one person-based metric (users/1000/year). RESULTS: The four opioids selected according to users/1000/year were tramadol (46.1), codeine and combination products (12.4 for codeine, 3.7 for codeine and acetylsalicylic acid, and 4.2 for codeine and paracetamol), morphine (17.0), and oxycodone (12.1). Overall utilisation according to volume and person metrics increased for all except codeine and combination products. Tramadol doses or strength increased, albeit less with increasing age. Oxycodone doses or strength decreased for all age groups but were nearly unchanged for the age group ≥ 80 years. CONCLUSION: Tramadol is the most utilised opioid in Denmark and was prescribed at increasing doses or strengths over the study period, particularly in the younger (< 80 years) age groups. Overall, oxycodone was prescribed at decreasing doses or strengths over time but remained unchanged for the age group ≥ 80 years. There is a need to address the pharmacological treatment of pain in terms of age, with tramadol and oxycodone being possible targets for regulatory efforts. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s40801-019-00163-w) contains supplementary material, which is available to authorized users. Springer International Publishing 2019-09-18 /pmc/articles/PMC6879688/ /pubmed/31535353 http://dx.doi.org/10.1007/s40801-019-00163-w Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Research Article Nissen, Søren Kabell Pottegård, Anton Ryg, Jesper Trends of Opioid Utilisation in Denmark: A Nationwide Study |
title | Trends of Opioid Utilisation in Denmark: A Nationwide Study |
title_full | Trends of Opioid Utilisation in Denmark: A Nationwide Study |
title_fullStr | Trends of Opioid Utilisation in Denmark: A Nationwide Study |
title_full_unstemmed | Trends of Opioid Utilisation in Denmark: A Nationwide Study |
title_short | Trends of Opioid Utilisation in Denmark: A Nationwide Study |
title_sort | trends of opioid utilisation in denmark: a nationwide study |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879688/ https://www.ncbi.nlm.nih.gov/pubmed/31535353 http://dx.doi.org/10.1007/s40801-019-00163-w |
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