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Mycobacterial OtsA Structures Unveil Substrate Preference Mechanism and Allosteric Regulation by 2-Oxoglutarate and 2-Phosphoglycerate

Trehalose is an essential disaccharide for mycobacteria and a key constituent of several cell wall glycolipids with fundamental roles in pathogenesis. Mycobacteria possess two pathways for trehalose biosynthesis. However, only the OtsAB pathway was found to be essential in Mycobacterium tuberculosis...

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Detalles Bibliográficos
Autores principales:	Mendes, Vítor, Acebrón-García-de-Eulate, Marta, Verma, Nupur, Blaszczyk, Michal, Dias, Márcio V. B., Blundell, Tom L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879718/ https://www.ncbi.nlm.nih.gov/pubmed/31772052 http://dx.doi.org/10.1128/mBio.02272-19

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