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A functionalized hydroxydopamine quinone links thiol modification to neuronal cell death

Recent findings suggest that dopamine oxidation contributes to the development of Parkinson's disease (PD); however, the mechanistic details remain elusive. Here, we compare 6-hydroxydopamine (6-OHDA), a product of dopamine oxidation that commonly induces dopaminergic neurodegeneration in labor...

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Detalles Bibliográficos
Autores principales: Farzam, Ali, Chohan, Karan, Strmiskova, Miroslava, Hewitt, Sarah J., Park, David S., Pezacki, John P., Özcelik, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880099/
https://www.ncbi.nlm.nih.gov/pubmed/31760358
http://dx.doi.org/10.1016/j.redox.2019.101377