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Association between thiopurine medication exposure and Alzheimer's disease among a cohort of patients with inflammatory bowel disease

INTRODUCTION: Ras-related C3 botulinum toxin substrate 1 (Rac1), a member of the Rho-GTPase family of proteins, could be an Alzheimer's disease (AD) triggering co-factor due to its effect on both amyloid precursor protein (APP) and tau. Thiopurine medications, such as azathioprine and mercaptop...

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Detalles Bibliográficos
Autores principales:	Sutton, S.Scott, Magagnoli, Joseph, Cummings, Tammy, Hardin, James W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880128/ https://www.ncbi.nlm.nih.gov/pubmed/31788536 http://dx.doi.org/10.1016/j.trci.2019.10.002

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