Cargando…

Small-Molecule Antiviral β-d-N(4)-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

Coronaviruses (CoVs) have emerged from animal reservoirs to cause severe and lethal disease in humans, but there are currently no FDA-approved antivirals to treat the infections. One class of antiviral compounds, nucleoside analogues, mimics naturally occurring nucleosides to inhibit viral replicati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Agostini, Maria L., Pruijssers, Andrea J., Chappell, James D., Gribble, Jennifer, Lu, Xiaotao, Andres, Erica L., Bluemling, Gregory R., Lockwood, Mark A., Sheahan, Timothy P., Sims, Amy C., Natchus, Michael G., Saindane, Manohar, Kolykhalov, Alexander A., Painter, George R., Baric, Ralph S., Denison, Mark R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Vaccines and Antiviral Agents
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880162/ https://www.ncbi.nlm.nih.gov/pubmed/31578288 http://dx.doi.org/10.1128/JVI.01348-19

Ejemplares similares

Analysis of the Potential for N(4)-Hydroxycytidine To Inhibit Mitochondrial Replication and Function
por: Sticher, Zachary M., et al.
Publicado: (2020)

ATI-2173, a Novel Liver-Targeted Non-Chain-Terminating Nucleotide for Hepatitis B Virus Cure Regimens
por: Squires, Katherine E., et al.
Publicado: (2020)

Simple In Vitro Assay To Evaluate the Incorporation Efficiency of Ribonucleotide Analog 5′-Triphosphates into RNA by Human Mitochondrial DNA-Dependent RNA Polymerase
por: Lu, Gaofei, et al.
Publicado: (2018)

Development of a Broadly Accessible Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine Platform
por: Agnihothram, Sudhakar, et al.
Publicado: (2018)

Evaluation of in vitro antiviral activity of SARS-CoV-2 M(pro) inhibitor pomotrelvir and cross-resistance to nirmatrelvir resistance substitutions
por: Tong, Xiao, et al.
Publicado: (2023)

Comparison of Subgenomic and Total RNA in SARS-CoV-2-Challenged Rhesus Macaques
por: Dagotto, Gabriel, et al.
Publicado: (2021)

Deletion of the SARS-CoV-2 Spike Cytoplasmic Tail Increases Infectivity in Pseudovirus Neutralization Assays
por: Yu, Jingyou, et al.
Publicado: (2021)

Protective Efficacy of Rhesus Adenovirus COVID-19 Vaccines against Mouse-Adapted SARS-CoV-2
por: Tostanoski, Lisa H., et al.
Publicado: (2021)

Vaccination of Macaques with DNA Followed by Adenoviral Vectors Encoding Simian Immunodeficiency Virus (SIV) Gag Alone Delays Infection by Repeated Mucosal Challenge with SIV
por: Almond, Neil, et al.
Publicado: (2019)

Contribution of Neuraminidase to the Efficacy of Seasonal Split Influenza Vaccines in the Ferret Model
por: Rosu, Miruna E., et al.
Publicado: (2022)

Characterization of Antibody Interactions with the G Protein of Vesicular Stomatitis Virus Indiana Strain and Other Vesiculovirus G Proteins
por: Munis, Altar M., et al.
Publicado: (2018)

A Bifluorescent-Based Assay for the Identification of Neutralizing Antibodies against SARS-CoV-2 Variants of Concern In Vitro and In Vivo
por: Chiem, Kevin, et al.
Publicado: (2021)

Identification of an Antiretroviral Small Molecule That Appears To Be a Host-Targeting Inhibitor of HIV-1 Assembly
por: Reed, Jonathan C., et al.
Publicado: (2021)

Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication
por: Guedán, Anabel, et al.
Publicado: (2017)

Impact of T(h)1 CD4 Follicular Helper T Cell Skewing on Antibody Responses to an HIV-1 Vaccine in Rhesus Macaques
por: Verma, Anil, et al.
Publicado: (2020)

Immunization of Pigs by DNA Prime and Recombinant Vaccinia Virus Boost To Identify and Rank African Swine Fever Virus Immunogenic and Protective Proteins
por: Jancovich, James K., et al.
Publicado: (2018)

Role of the E2 Hypervariable Region (HVR1) in the Immunogenicity of a Recombinant Hepatitis C Virus Vaccine
por: Law, John L. M., et al.
Publicado: (2018)

Vaccines That Reduce Viral Shedding Do Not Prevent Transmission of H1N1 Pandemic 2009 Swine Influenza A Virus Infection to Unvaccinated Pigs
por: Everett, Helen E., et al.
Publicado: (2021)

SARS-CoV-2 and Influenza A Virus Coinfections in Ferrets
por: Huang, Ying, et al.
Publicado: (2022)

Bridging Vaccine-Induced HIV-1 Neutralizing and Effector Antibody Responses in Rabbit and Rhesus Macaque Animal Models
por: Pollara, Justin, et al.
Publicado: (2019)

Autologous Antibody Responses to an HIV Envelope Glycan Hole Are Not Easily Broadened in Rabbits
por: Yang, Yuhe R., et al.
Publicado: (2020)

Alternative Strategy for a Quadrivalent Live Attenuated Influenza Virus Vaccine
por: Wan, Zhimin, et al.
Publicado: (2018)

Evasion of a Human Cytomegalovirus Entry Inhibitor with Potent Cysteine Reactivity Is Concomitant with the Utilization of a Heparan Sulfate Proteoglycan-Independent Route of Entry
por: Murray, M. J., et al.
Publicado: (2020)

A Virion-Based Combination Vaccine Protects against Influenza and SARS-CoV-2 Disease in Mice
por: Chaparian, Ryan R., et al.
Publicado: (2022)

Broad Anti-coronavirus Activity of Food and Drug Administration-Approved Drugs against SARS-CoV-2 In Vitro and SARS-CoV In Vivo
por: Weston, Stuart, et al.
Publicado: (2020)

Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein
por: van Haaren, M. M., et al.
Publicado: (2021)

A Methyltransferase-Defective Vesicular Stomatitis Virus-Based SARS-CoV-2 Vaccine Candidate Provides Complete Protection against SARS-CoV-2 Infection in Hamsters
por: Lu, Mijia, et al.
Publicado: (2021)

Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses
por: Crosby, Catherine M., et al.
Publicado: (2017)

Effect of an Adenovirus-Vectored Universal Influenza Virus Vaccine on Pulmonary Pathophysiology in a Mouse Model
por: Dhakal, Santosh, et al.
Publicado: (2021)

Adenovirus Vector Vaccination Impacts NK Cell Rheostat Function following Lymphocytic Choriomeningitis Virus Infection
por: Blass, Eryn, et al.
Publicado: (2018)

Development of an Alternative Modified Live Influenza B Virus Vaccine
por: Santos, Jefferson J. S., et al.
Publicado: (2017)

Broadly Inhibiting Antineuraminidase Monoclonal Antibodies Induced by Trivalent Influenza Vaccine and H7N9 Infection in Humans
por: Rijal, Pramila, et al.
Publicado: (2020)

A Recombinant VSV-Based Bivalent Vaccine Effectively Protects against Both SARS-CoV-2 and Influenza A Virus Infection
por: Ao, Zhujun, et al.
Publicado: (2022)

Antigenic Characterization of Human Monoclonal Antibodies for Therapeutic Use against H7N9 Avian Influenza Virus
por: Chang, Pengxiang, et al.
Publicado: (2022)

Inactivated H7 Influenza Virus Vaccines Protect Mice despite Inducing Only Low Levels of Neutralizing Antibodies
por: Kamal, Ram P., et al.
Publicado: (2017)

Panels of HIV-1 Subtype C Env Reference Strains for Standardized Neutralization Assessments
por: Hraber, Peter, et al.
Publicado: (2017)

Zika Virus-Like Particles Bearing a Covalent Dimer of Envelope Protein Protect Mice from Lethal Challenge
por: De Lorenzo, Giuditta, et al.
Publicado: (2020)

Molecular Basis of the Divergent Immunogenicity of Two Pediatric Tick-Borne Encephalitis Virus Vaccines
por: Beck, Yvonne, et al.
Publicado: (2016)

A Recombinant Hepatitis C Virus Genotype 1a E1/E2 Envelope Glycoprotein Vaccine Elicits Antibodies That Differentially Neutralize Closely Related 2a Strains through Interactions of the N-Terminal Hypervariable Region 1 of E2 with Scavenger Receptor B1
por: Johnson, Janelle, et al.
Publicado: (2019)

Generation of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity
por: Donius, Luke R., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_82t1qp33tnk80saa28o3davuhv