Differentiation into an Effector Memory Phenotype Potentiates HIV-1 Latency Reversal in CD4(+) T Cells

During antiretroviral therapy (ART), human immunodeficiency virus type 1 (HIV-1) persists as a latent reservoir in CD4(+) T cell subsets in central memory (T(CM)), transitional memory (T(TM)), and effector memory (T(EM)) CD4(+) T cells. We have identified differences in mechanisms underlying latency...

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Detalles Bibliográficos
Autores principales: Kulpa, Deanna A., Talla, Aarthi, Brehm, Jessica H., Ribeiro, Susan Pereira, Yuan, Sally, Bebin-Blackwell, Anne-Gaelle, Miller, Michael, Barnard, Richard, Deeks, Steven G., Hazuda, Daria, Chomont, Nicolas, Sékaly, Rafick-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880164/
https://www.ncbi.nlm.nih.gov/pubmed/31578289
http://dx.doi.org/10.1128/JVI.00969-19

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