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Expanding the uses of genome‐scale models with protein structures
Biology is reaching a convergence point of its historic reductionist and modern holistic approaches to understanding the living system. Structural biology has historically taken the reductionist approach to deeply probe the inner workings of complex molecular machines. In contrast, systems biology a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880182/ https://www.ncbi.nlm.nih.gov/pubmed/31777175 http://dx.doi.org/10.15252/msb.20188601 |
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author | Mih, Nathan Palsson, Bernhard O |
author_facet | Mih, Nathan Palsson, Bernhard O |
author_sort | Mih, Nathan |
collection | PubMed |
description | Biology is reaching a convergence point of its historic reductionist and modern holistic approaches to understanding the living system. Structural biology has historically taken the reductionist approach to deeply probe the inner workings of complex molecular machines. In contrast, systems biology and genome‐scale modeling have organically grown out of the wealth of data now being generated by diverse omics measurements. In the late 2000s, a proposed interdisciplinary field of structural systems biology pitched the merger of these two approaches, with widespread applications in pharmacology, disease modeling, protein engineering, and evolutionary studies. In this commentary, we highlight the challenges of integrating these two fields, with a focus on genome‐scale metabolic modeling, and the novel findings that are made possible from such a merger. |
format | Online Article Text |
id | pubmed-6880182 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-68801822019-11-29 Expanding the uses of genome‐scale models with protein structures Mih, Nathan Palsson, Bernhard O Mol Syst Biol Commentary Biology is reaching a convergence point of its historic reductionist and modern holistic approaches to understanding the living system. Structural biology has historically taken the reductionist approach to deeply probe the inner workings of complex molecular machines. In contrast, systems biology and genome‐scale modeling have organically grown out of the wealth of data now being generated by diverse omics measurements. In the late 2000s, a proposed interdisciplinary field of structural systems biology pitched the merger of these two approaches, with widespread applications in pharmacology, disease modeling, protein engineering, and evolutionary studies. In this commentary, we highlight the challenges of integrating these two fields, with a focus on genome‐scale metabolic modeling, and the novel findings that are made possible from such a merger. John Wiley and Sons Inc. 2019-11-26 /pmc/articles/PMC6880182/ /pubmed/31777175 http://dx.doi.org/10.15252/msb.20188601 Text en © 2019 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Commentary Mih, Nathan Palsson, Bernhard O Expanding the uses of genome‐scale models with protein structures |
title | Expanding the uses of genome‐scale models with protein structures |
title_full | Expanding the uses of genome‐scale models with protein structures |
title_fullStr | Expanding the uses of genome‐scale models with protein structures |
title_full_unstemmed | Expanding the uses of genome‐scale models with protein structures |
title_short | Expanding the uses of genome‐scale models with protein structures |
title_sort | expanding the uses of genome‐scale models with protein structures |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880182/ https://www.ncbi.nlm.nih.gov/pubmed/31777175 http://dx.doi.org/10.15252/msb.20188601 |
work_keys_str_mv | AT mihnathan expandingtheusesofgenomescalemodelswithproteinstructures AT palssonbernhardo expandingtheusesofgenomescalemodelswithproteinstructures |