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Expanding the uses of genome‐scale models with protein structures

Biology is reaching a convergence point of its historic reductionist and modern holistic approaches to understanding the living system. Structural biology has historically taken the reductionist approach to deeply probe the inner workings of complex molecular machines. In contrast, systems biology a...

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Autores principales: Mih, Nathan, Palsson, Bernhard O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880182/
https://www.ncbi.nlm.nih.gov/pubmed/31777175
http://dx.doi.org/10.15252/msb.20188601
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author Mih, Nathan
Palsson, Bernhard O
author_facet Mih, Nathan
Palsson, Bernhard O
author_sort Mih, Nathan
collection PubMed
description Biology is reaching a convergence point of its historic reductionist and modern holistic approaches to understanding the living system. Structural biology has historically taken the reductionist approach to deeply probe the inner workings of complex molecular machines. In contrast, systems biology and genome‐scale modeling have organically grown out of the wealth of data now being generated by diverse omics measurements. In the late 2000s, a proposed interdisciplinary field of structural systems biology pitched the merger of these two approaches, with widespread applications in pharmacology, disease modeling, protein engineering, and evolutionary studies. In this commentary, we highlight the challenges of integrating these two fields, with a focus on genome‐scale metabolic modeling, and the novel findings that are made possible from such a merger.
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spelling pubmed-68801822019-11-29 Expanding the uses of genome‐scale models with protein structures Mih, Nathan Palsson, Bernhard O Mol Syst Biol Commentary Biology is reaching a convergence point of its historic reductionist and modern holistic approaches to understanding the living system. Structural biology has historically taken the reductionist approach to deeply probe the inner workings of complex molecular machines. In contrast, systems biology and genome‐scale modeling have organically grown out of the wealth of data now being generated by diverse omics measurements. In the late 2000s, a proposed interdisciplinary field of structural systems biology pitched the merger of these two approaches, with widespread applications in pharmacology, disease modeling, protein engineering, and evolutionary studies. In this commentary, we highlight the challenges of integrating these two fields, with a focus on genome‐scale metabolic modeling, and the novel findings that are made possible from such a merger. John Wiley and Sons Inc. 2019-11-26 /pmc/articles/PMC6880182/ /pubmed/31777175 http://dx.doi.org/10.15252/msb.20188601 Text en © 2019 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Mih, Nathan
Palsson, Bernhard O
Expanding the uses of genome‐scale models with protein structures
title Expanding the uses of genome‐scale models with protein structures
title_full Expanding the uses of genome‐scale models with protein structures
title_fullStr Expanding the uses of genome‐scale models with protein structures
title_full_unstemmed Expanding the uses of genome‐scale models with protein structures
title_short Expanding the uses of genome‐scale models with protein structures
title_sort expanding the uses of genome‐scale models with protein structures
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880182/
https://www.ncbi.nlm.nih.gov/pubmed/31777175
http://dx.doi.org/10.15252/msb.20188601
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