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Recent advances in tissue imaging for cancer research
Image analysis in clinical research has evolved at fast pace in the last decade. This review discusses basic concepts ranging from immunohistochemistry to advanced techniques such as multiplex imaging, digital pathology, flow cytometry and intravital microscopy. Tissue imaging ex vivo is still one o...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880269/ https://www.ncbi.nlm.nih.gov/pubmed/31824652 http://dx.doi.org/10.12688/f1000research.19037.1 |
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author | Maiques, Oscar Georgouli, Mirella Sanz-Moreno, Victoria |
author_facet | Maiques, Oscar Georgouli, Mirella Sanz-Moreno, Victoria |
author_sort | Maiques, Oscar |
collection | PubMed |
description | Image analysis in clinical research has evolved at fast pace in the last decade. This review discusses basic concepts ranging from immunohistochemistry to advanced techniques such as multiplex imaging, digital pathology, flow cytometry and intravital microscopy. Tissue imaging ex vivo is still one of the gold-standards in the field due to feasibility. We describe here different protocols and applications of digital analysis providing basic and clinical researchers with an overview on how to analyse tissue images. In vivo imaging is not easily accessible to researchers; however, it provides invaluable dynamic information. Overall, we discuss a plethora of techniques that - when combined - constitute a powerful platform for basic and translational cancer research. |
format | Online Article Text |
id | pubmed-6880269 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-68802692019-12-09 Recent advances in tissue imaging for cancer research Maiques, Oscar Georgouli, Mirella Sanz-Moreno, Victoria F1000Res Review Image analysis in clinical research has evolved at fast pace in the last decade. This review discusses basic concepts ranging from immunohistochemistry to advanced techniques such as multiplex imaging, digital pathology, flow cytometry and intravital microscopy. Tissue imaging ex vivo is still one of the gold-standards in the field due to feasibility. We describe here different protocols and applications of digital analysis providing basic and clinical researchers with an overview on how to analyse tissue images. In vivo imaging is not easily accessible to researchers; however, it provides invaluable dynamic information. Overall, we discuss a plethora of techniques that - when combined - constitute a powerful platform for basic and translational cancer research. F1000 Research Limited 2019-11-25 /pmc/articles/PMC6880269/ /pubmed/31824652 http://dx.doi.org/10.12688/f1000research.19037.1 Text en Copyright: © 2019 Maiques O et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Maiques, Oscar Georgouli, Mirella Sanz-Moreno, Victoria Recent advances in tissue imaging for cancer research |
title | Recent advances in tissue imaging for cancer research |
title_full | Recent advances in tissue imaging for cancer research |
title_fullStr | Recent advances in tissue imaging for cancer research |
title_full_unstemmed | Recent advances in tissue imaging for cancer research |
title_short | Recent advances in tissue imaging for cancer research |
title_sort | recent advances in tissue imaging for cancer research |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880269/ https://www.ncbi.nlm.nih.gov/pubmed/31824652 http://dx.doi.org/10.12688/f1000research.19037.1 |
work_keys_str_mv | AT maiquesoscar recentadvancesintissueimagingforcancerresearch AT georgoulimirella recentadvancesintissueimagingforcancerresearch AT sanzmorenovictoria recentadvancesintissueimagingforcancerresearch |