The role of chemotherapy in the treatment of central neurocytoma

AIM: Central neurocytoma (CN) is a rare WHO grade II central nervous system (CNS) tumor. This is an update on chemotherapeutic agents used in its treatment. PATIENTS & METHODS: An institutional review board-approved, chart review of patients seen at our institution resulted in a single case trea...

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Autores principales: Johnson, Margaret O, Kirkpatrick, John P, Patel, Mallika P, Desjardins, Annick, Randazzo, Dina M, Friedman, Henry S, Ashley, David M, Peters, Katherine B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2019
Materias:
Special Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880304/
https://www.ncbi.nlm.nih.gov/pubmed/31686534
http://dx.doi.org/10.2217/cns-2019-0012
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author Johnson, Margaret O
Kirkpatrick, John P
Patel, Mallika P
Desjardins, Annick
Randazzo, Dina M
Friedman, Henry S
Ashley, David M
Peters, Katherine B
author_facet Johnson, Margaret O
Kirkpatrick, John P
Patel, Mallika P
Desjardins, Annick
Randazzo, Dina M
Friedman, Henry S
Ashley, David M
Peters, Katherine B
author_sort Johnson, Margaret O
collection PubMed
description AIM: Central neurocytoma (CN) is a rare WHO grade II central nervous system (CNS) tumor. This is an update on chemotherapeutic agents used in its treatment. PATIENTS & METHODS: An institutional review board-approved, chart review of patients seen at our institution resulted in a single case treated with chemotherapy and is herein included. We proceeded with a comprehensive literature review. RESULTS: We identified 18 citations, representing 39 cases of adult and pediatric CN treated with chemotherapy. With the addition of our single case, the total number of recurrent CN patients treated with temozolomide (TMZ) is nine. CONCLUSION: There exists marked heterogeneity in chemotherapy used to treat CN. TMZ is incorporated into treatment regimens in the setting of tumor recurrence: its role merits further study.
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spelling pubmed-68803042019-12-03 The role of chemotherapy in the treatment of central neurocytoma Johnson, Margaret O Kirkpatrick, John P Patel, Mallika P Desjardins, Annick Randazzo, Dina M Friedman, Henry S Ashley, David M Peters, Katherine B CNS Oncol Special Report AIM: Central neurocytoma (CN) is a rare WHO grade II central nervous system (CNS) tumor. This is an update on chemotherapeutic agents used in its treatment. PATIENTS & METHODS: An institutional review board-approved, chart review of patients seen at our institution resulted in a single case treated with chemotherapy and is herein included. We proceeded with a comprehensive literature review. RESULTS: We identified 18 citations, representing 39 cases of adult and pediatric CN treated with chemotherapy. With the addition of our single case, the total number of recurrent CN patients treated with temozolomide (TMZ) is nine. CONCLUSION: There exists marked heterogeneity in chemotherapy used to treat CN. TMZ is incorporated into treatment regimens in the setting of tumor recurrence: its role merits further study. Future Medicine Ltd 2019-11-05 /pmc/articles/PMC6880304/ /pubmed/31686534 http://dx.doi.org/10.2217/cns-2019-0012 Text en © 2019 Margaret O Johnson This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Special Report
Johnson, Margaret O
Kirkpatrick, John P
Patel, Mallika P
Desjardins, Annick
Randazzo, Dina M
Friedman, Henry S
Ashley, David M
Peters, Katherine B
The role of chemotherapy in the treatment of central neurocytoma
title The role of chemotherapy in the treatment of central neurocytoma
title_full The role of chemotherapy in the treatment of central neurocytoma
title_fullStr The role of chemotherapy in the treatment of central neurocytoma
title_full_unstemmed The role of chemotherapy in the treatment of central neurocytoma
title_short The role of chemotherapy in the treatment of central neurocytoma
title_sort role of chemotherapy in the treatment of central neurocytoma
topic Special Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880304/
https://www.ncbi.nlm.nih.gov/pubmed/31686534
http://dx.doi.org/10.2217/cns-2019-0012
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