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Analysing detection of chronic diseases with prolonged sub-clinical periods: modelling and application to hypertension in the U.S.
BACKGROUND: We recently introduced a system of partial differential equations (PDEs) to model the prevalence of chronic diseases with a possibly prolonged state of asymptomatic, undiagnosed disease preceding a diagnosis. Common examples for such diseases include coronary heart disease, type 2 diabet...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880443/ https://www.ncbi.nlm.nih.gov/pubmed/31775635 http://dx.doi.org/10.1186/s12874-019-0845-2 |
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author | Brinks, Ralph Kaufmann, Sophie Hoyer, Annika Gregg, Edward W Saal, Jürgen |
author_facet | Brinks, Ralph Kaufmann, Sophie Hoyer, Annika Gregg, Edward W Saal, Jürgen |
author_sort | Brinks, Ralph |
collection | PubMed |
description | BACKGROUND: We recently introduced a system of partial differential equations (PDEs) to model the prevalence of chronic diseases with a possibly prolonged state of asymptomatic, undiagnosed disease preceding a diagnosis. Common examples for such diseases include coronary heart disease, type 2 diabetes or cancer. Widespread application of the new method depends upon mathematical treatment of the system of PDEs. METHODS: In this article, we study the existence and the uniqueness of the solution of the system of PDEs. To demonstrate the usefulness and importance of the system, we model the age-specific prevalence of hypertension in the US 1999–2010. RESULTS: The examinations of mathematical properties provide a way to solve the systems of PDEs by the method of characteristics. In the application to hypertension, we obtain a good agreement between modeled and surveyed age-specific prevalences. CONCLUSIONS: The described system of PDEs provides a practical way to examine the epidemiology of chronic diseases with a state of undiagnosed disease preceding a diagnosis. |
format | Online Article Text |
id | pubmed-6880443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-68804432019-11-29 Analysing detection of chronic diseases with prolonged sub-clinical periods: modelling and application to hypertension in the U.S. Brinks, Ralph Kaufmann, Sophie Hoyer, Annika Gregg, Edward W Saal, Jürgen BMC Med Res Methodol Research Article BACKGROUND: We recently introduced a system of partial differential equations (PDEs) to model the prevalence of chronic diseases with a possibly prolonged state of asymptomatic, undiagnosed disease preceding a diagnosis. Common examples for such diseases include coronary heart disease, type 2 diabetes or cancer. Widespread application of the new method depends upon mathematical treatment of the system of PDEs. METHODS: In this article, we study the existence and the uniqueness of the solution of the system of PDEs. To demonstrate the usefulness and importance of the system, we model the age-specific prevalence of hypertension in the US 1999–2010. RESULTS: The examinations of mathematical properties provide a way to solve the systems of PDEs by the method of characteristics. In the application to hypertension, we obtain a good agreement between modeled and surveyed age-specific prevalences. CONCLUSIONS: The described system of PDEs provides a practical way to examine the epidemiology of chronic diseases with a state of undiagnosed disease preceding a diagnosis. BioMed Central 2019-11-27 /pmc/articles/PMC6880443/ /pubmed/31775635 http://dx.doi.org/10.1186/s12874-019-0845-2 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Brinks, Ralph Kaufmann, Sophie Hoyer, Annika Gregg, Edward W Saal, Jürgen Analysing detection of chronic diseases with prolonged sub-clinical periods: modelling and application to hypertension in the U.S. |
title | Analysing detection of chronic diseases with prolonged sub-clinical periods: modelling and application to hypertension in the U.S. |
title_full | Analysing detection of chronic diseases with prolonged sub-clinical periods: modelling and application to hypertension in the U.S. |
title_fullStr | Analysing detection of chronic diseases with prolonged sub-clinical periods: modelling and application to hypertension in the U.S. |
title_full_unstemmed | Analysing detection of chronic diseases with prolonged sub-clinical periods: modelling and application to hypertension in the U.S. |
title_short | Analysing detection of chronic diseases with prolonged sub-clinical periods: modelling and application to hypertension in the U.S. |
title_sort | analysing detection of chronic diseases with prolonged sub-clinical periods: modelling and application to hypertension in the u.s. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880443/ https://www.ncbi.nlm.nih.gov/pubmed/31775635 http://dx.doi.org/10.1186/s12874-019-0845-2 |
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