Microtubule destabilization caused by silicate via HDAC6 activation contributes to autophagic dysfunction in bone mesenchymal stem cells

BACKGROUND: Silicon-modified biomaterials have been extensively studied in bone tissue engineering. In recent years, the toxicity of silicon-doped biomaterials has gradually attracted attention but requires further elucidation. This study was designed to explore whether high-dose silicate can induce...

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Detalles Bibliográficos
Autores principales: Li, Zheng, Liu, Shuhao, Fu, Tengfei, Peng, Yi, Zhang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880487/
https://www.ncbi.nlm.nih.gov/pubmed/31775910
http://dx.doi.org/10.1186/s13287-019-1441-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880487/
https://www.ncbi.nlm.nih.gov/pubmed/31775910
http://dx.doi.org/10.1186/s13287-019-1441-4

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