Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer

BACKGROUND: Human pancreatic ductal adenocarcinoma (PDAC) responds poorly to immune checkpoint inhibitor (ICPi). While the mechanism is not completely clear, it has been recognized that tumor microenvironment (TME) plays key roles. We investigated if targeting CD47 with a monoclonal antibody could e...

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Detalles Bibliográficos
Autores principales: Pan, Yu, Lu, Fengchun, Fei, Qinglin, Yu, Xingxing, Xiong, Ping, Yu, Xunbin, Dang, Yuan, Hou, Zelin, Lin, Wenji, Lin, Xianchao, Zhang, Zheyang, Pan, Minggui, Huang, Heguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880569/
https://www.ncbi.nlm.nih.gov/pubmed/31771616
http://dx.doi.org/10.1186/s13045-019-0822-6

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