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Respiratory syncytial virus-associated mortality in a healthy 3-year-old child: a case report
BACKGROUND: Respiratory syncytial virus (RSV) is the most frequently identified pathogen in children with acute lower respiratory tract infection. Fatal cases have mainly been reported during the first 6 months of life or in the presence of comorbidity. CASE PRESENTATION: A 47-month-old girl was adm...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880595/ https://www.ncbi.nlm.nih.gov/pubmed/31771554 http://dx.doi.org/10.1186/s12887-019-1847-2 |
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author | Gavotto, A. Ousselin, A. Pidoux, O. Cathala, P. Costes-Martineau, V. Rivière, B. Pasquié, J. L. Amedro, P. Rambaud, C. Cambonie, G. |
author_facet | Gavotto, A. Ousselin, A. Pidoux, O. Cathala, P. Costes-Martineau, V. Rivière, B. Pasquié, J. L. Amedro, P. Rambaud, C. Cambonie, G. |
author_sort | Gavotto, A. |
collection | PubMed |
description | BACKGROUND: Respiratory syncytial virus (RSV) is the most frequently identified pathogen in children with acute lower respiratory tract infection. Fatal cases have mainly been reported during the first 6 months of life or in the presence of comorbidity. CASE PRESENTATION: A 47-month-old girl was admitted to the pediatric intensive care unit following sudden cardiopulmonary arrest occurring at home. The electrocardiogram showed cardiac asystole, which was refractory to prolonged resuscitation efforts. Postmortem analyses detected RSV by polymerase chain reaction in an abundant, exudative pericardial effusion. Histopathological examination was consistent with viral myoepicarditis, including an inflammatory process affecting cardiac nerves and ganglia. Molecular analysis of sudden unexplained death genes identified a heterozygous mutation in myosin light chain 2, which was also found in two other healthy members of the family. Additional expert interpretation of the cardiac histology confirmed the absence of arrhythmogenic right ventricular dysplasia or hypertrophic cardiomyopathy. CONCLUSIONS: RSV-related sudden death in a normally developing child of this age is exceptional. This case highlights the risk of extrapulmonary manifestations associated with this infection, particularly arrhythmia induced by inflammatory phenomena affecting the cardiac autonomic nervous system. The role of the mutation in this context is uncertain, and it is therefore necessary to continue to assess how this pathogenic variant contributes to unexpected sudden death in childhood. |
format | Online Article Text |
id | pubmed-6880595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-68805952019-12-03 Respiratory syncytial virus-associated mortality in a healthy 3-year-old child: a case report Gavotto, A. Ousselin, A. Pidoux, O. Cathala, P. Costes-Martineau, V. Rivière, B. Pasquié, J. L. Amedro, P. Rambaud, C. Cambonie, G. BMC Pediatr Case Report BACKGROUND: Respiratory syncytial virus (RSV) is the most frequently identified pathogen in children with acute lower respiratory tract infection. Fatal cases have mainly been reported during the first 6 months of life or in the presence of comorbidity. CASE PRESENTATION: A 47-month-old girl was admitted to the pediatric intensive care unit following sudden cardiopulmonary arrest occurring at home. The electrocardiogram showed cardiac asystole, which was refractory to prolonged resuscitation efforts. Postmortem analyses detected RSV by polymerase chain reaction in an abundant, exudative pericardial effusion. Histopathological examination was consistent with viral myoepicarditis, including an inflammatory process affecting cardiac nerves and ganglia. Molecular analysis of sudden unexplained death genes identified a heterozygous mutation in myosin light chain 2, which was also found in two other healthy members of the family. Additional expert interpretation of the cardiac histology confirmed the absence of arrhythmogenic right ventricular dysplasia or hypertrophic cardiomyopathy. CONCLUSIONS: RSV-related sudden death in a normally developing child of this age is exceptional. This case highlights the risk of extrapulmonary manifestations associated with this infection, particularly arrhythmia induced by inflammatory phenomena affecting the cardiac autonomic nervous system. The role of the mutation in this context is uncertain, and it is therefore necessary to continue to assess how this pathogenic variant contributes to unexpected sudden death in childhood. BioMed Central 2019-11-27 /pmc/articles/PMC6880595/ /pubmed/31771554 http://dx.doi.org/10.1186/s12887-019-1847-2 Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Gavotto, A. Ousselin, A. Pidoux, O. Cathala, P. Costes-Martineau, V. Rivière, B. Pasquié, J. L. Amedro, P. Rambaud, C. Cambonie, G. Respiratory syncytial virus-associated mortality in a healthy 3-year-old child: a case report |
title | Respiratory syncytial virus-associated mortality in a healthy 3-year-old child: a case report |
title_full | Respiratory syncytial virus-associated mortality in a healthy 3-year-old child: a case report |
title_fullStr | Respiratory syncytial virus-associated mortality in a healthy 3-year-old child: a case report |
title_full_unstemmed | Respiratory syncytial virus-associated mortality in a healthy 3-year-old child: a case report |
title_short | Respiratory syncytial virus-associated mortality in a healthy 3-year-old child: a case report |
title_sort | respiratory syncytial virus-associated mortality in a healthy 3-year-old child: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880595/ https://www.ncbi.nlm.nih.gov/pubmed/31771554 http://dx.doi.org/10.1186/s12887-019-1847-2 |
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