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Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses

OBJECTIVE: The purpose of this study was (1) to perform a summary of meta-analyses comparing platelet-rich plasma (PRP) injection with hyaluronic acid (HA) and placebo injection for KOA patients, (2) to determine which meta-analysis provides the best available evidence to making proposals for the us...

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Autores principales: Chen, Pu, Huang, Liuwei, Ma, Yufeng, Zhang, Dong, Zhang, Xiaozhe, Zhou, Jun, Ruan, Anmin, Wang, Qingfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880602/
https://www.ncbi.nlm.nih.gov/pubmed/31775816
http://dx.doi.org/10.1186/s13018-019-1363-y
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author Chen, Pu
Huang, Liuwei
Ma, Yufeng
Zhang, Dong
Zhang, Xiaozhe
Zhou, Jun
Ruan, Anmin
Wang, Qingfu
author_facet Chen, Pu
Huang, Liuwei
Ma, Yufeng
Zhang, Dong
Zhang, Xiaozhe
Zhou, Jun
Ruan, Anmin
Wang, Qingfu
author_sort Chen, Pu
collection PubMed
description OBJECTIVE: The purpose of this study was (1) to perform a summary of meta-analyses comparing platelet-rich plasma (PRP) injection with hyaluronic acid (HA) and placebo injection for KOA patients, (2) to determine which meta-analysis provides the best available evidence to making proposals for the use of PRP in the treatment of KOA patients, and (3) to highlight gaps in the literature that require future investigation. MATERIAL AND METHODS: PubMed, EMBASE, and Cochrane databases search were performed for meta-analyses which compared PRP injection with HA or placebo. Clinical outcomes and adverse events were extracted from these meta-analyses. Meta-analysis quality was assessed using the Quality of Reporting of Meta-analyses (QUOROM) systems and the Oxman-Guyatt quality appraisal tool. The Jadad decision algorithm was also used to determine which meta-analysis provided the best available evidence. RESULTS: Four meta-analyses were included in our study, and all of these articles were Level I evidence. The QUOROM score of each included meta-analysis range from 14 to 17 points (mean score 15, maximum score 18), and the Oxman-Guyatt score range from 4 to 6 points (mean score 5, maximum score 7). Three meta-analyses indicated PRP showed more benefit in pain relief and functional improvement than the control group, and the other one suggested no difference between these groups. All included meta-analyses found no statistical difference in adverse events between these groups. In addition, a meta-analysis conducted by Shen et al. got the highest methodological quality score and suggested that PRP provided better pain relief and function improvement in the treatment of KOA. CONCLUSIONS: For short-term follow-up (≤1 year), intra-articular PRP injection is more effective in terms of pain relief and function improvement in the treatment of KOA patients than HA and placebo, and there is no difference in the risk of an adverse event between PRP and HA or placebo. LEVEL OF EVIDENCE: Level I evidence, a summary of meta-analyses TRIAL REGISTRATION: PROSPERO ID CRD42018116168
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spelling pubmed-68806022019-12-03 Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses Chen, Pu Huang, Liuwei Ma, Yufeng Zhang, Dong Zhang, Xiaozhe Zhou, Jun Ruan, Anmin Wang, Qingfu J Orthop Surg Res Research Article OBJECTIVE: The purpose of this study was (1) to perform a summary of meta-analyses comparing platelet-rich plasma (PRP) injection with hyaluronic acid (HA) and placebo injection for KOA patients, (2) to determine which meta-analysis provides the best available evidence to making proposals for the use of PRP in the treatment of KOA patients, and (3) to highlight gaps in the literature that require future investigation. MATERIAL AND METHODS: PubMed, EMBASE, and Cochrane databases search were performed for meta-analyses which compared PRP injection with HA or placebo. Clinical outcomes and adverse events were extracted from these meta-analyses. Meta-analysis quality was assessed using the Quality of Reporting of Meta-analyses (QUOROM) systems and the Oxman-Guyatt quality appraisal tool. The Jadad decision algorithm was also used to determine which meta-analysis provided the best available evidence. RESULTS: Four meta-analyses were included in our study, and all of these articles were Level I evidence. The QUOROM score of each included meta-analysis range from 14 to 17 points (mean score 15, maximum score 18), and the Oxman-Guyatt score range from 4 to 6 points (mean score 5, maximum score 7). Three meta-analyses indicated PRP showed more benefit in pain relief and functional improvement than the control group, and the other one suggested no difference between these groups. All included meta-analyses found no statistical difference in adverse events between these groups. In addition, a meta-analysis conducted by Shen et al. got the highest methodological quality score and suggested that PRP provided better pain relief and function improvement in the treatment of KOA. CONCLUSIONS: For short-term follow-up (≤1 year), intra-articular PRP injection is more effective in terms of pain relief and function improvement in the treatment of KOA patients than HA and placebo, and there is no difference in the risk of an adverse event between PRP and HA or placebo. LEVEL OF EVIDENCE: Level I evidence, a summary of meta-analyses TRIAL REGISTRATION: PROSPERO ID CRD42018116168 BioMed Central 2019-11-27 /pmc/articles/PMC6880602/ /pubmed/31775816 http://dx.doi.org/10.1186/s13018-019-1363-y Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Chen, Pu
Huang, Liuwei
Ma, Yufeng
Zhang, Dong
Zhang, Xiaozhe
Zhou, Jun
Ruan, Anmin
Wang, Qingfu
Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses
title Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses
title_full Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses
title_fullStr Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses
title_full_unstemmed Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses
title_short Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses
title_sort intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880602/
https://www.ncbi.nlm.nih.gov/pubmed/31775816
http://dx.doi.org/10.1186/s13018-019-1363-y
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