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Microstructural changes in the brain in elderly patients with irritable bowel syndrome

OBJECTIVE: It is unclear how alterations in gray matter volume and white matter density affect elderly patients with irritable bowel syndrome (IBS). This study aimed to investigate the relationship between structural changes in the brain and psychological stress in elderly IBS patients. METHODS: Eig...

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Autores principales: Zhao, Lanlan, Wang, Yuezhi, Zhang, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880712/
https://www.ncbi.nlm.nih.gov/pubmed/31942491
http://dx.doi.org/10.1002/agm2.12034
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author Zhao, Lanlan
Wang, Yuezhi
Zhang, Yu
author_facet Zhao, Lanlan
Wang, Yuezhi
Zhang, Yu
author_sort Zhao, Lanlan
collection PubMed
description OBJECTIVE: It is unclear how alterations in gray matter volume and white matter density affect elderly patients with irritable bowel syndrome (IBS). This study aimed to investigate the relationship between structural changes in the brain and psychological stress in elderly IBS patients. METHODS: Eighteen IBS patients and 12 healthy controls underwent structural magnetic resonance imaging. Voxel‐based morphometry and diffusion tensor imaging analysis were used to identify abnormalities in cortical regions and white matter, respectively. RESULTS: The IBS group showed a significant GMV reduction in the cingulate gyrus, occipital lobe, hippocampus, frontal lobe, medial frontal gyrus, superior frontal gyrus, and limbic lobe as well as a higher GMV in the insula, superior temporal gyrus, angular gyrus, and supramarginal gyrus. Diffusion tensor imaging indicated that the IBS group had lower fractional anisotropy in the corpus callosum, upper corona, fornix, internal capsule, and brainstem. Additionally, IBS patients showed higher mean diffusivity in the cingulate gyrus, corpus callosum, upper corona, internal capsule, external capsule, fornix, and superior longitudinal fasciculus. CONCLUSION: Structural changes in the brain play a role in the condition of elderly IBS patients. Psychological stress is an important factor for developing IBS via the hypothalamic‐pituitary‐adrenal axis.
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spelling pubmed-68807122020-01-15 Microstructural changes in the brain in elderly patients with irritable bowel syndrome Zhao, Lanlan Wang, Yuezhi Zhang, Yu Aging Med (Milton) Original Articles OBJECTIVE: It is unclear how alterations in gray matter volume and white matter density affect elderly patients with irritable bowel syndrome (IBS). This study aimed to investigate the relationship between structural changes in the brain and psychological stress in elderly IBS patients. METHODS: Eighteen IBS patients and 12 healthy controls underwent structural magnetic resonance imaging. Voxel‐based morphometry and diffusion tensor imaging analysis were used to identify abnormalities in cortical regions and white matter, respectively. RESULTS: The IBS group showed a significant GMV reduction in the cingulate gyrus, occipital lobe, hippocampus, frontal lobe, medial frontal gyrus, superior frontal gyrus, and limbic lobe as well as a higher GMV in the insula, superior temporal gyrus, angular gyrus, and supramarginal gyrus. Diffusion tensor imaging indicated that the IBS group had lower fractional anisotropy in the corpus callosum, upper corona, fornix, internal capsule, and brainstem. Additionally, IBS patients showed higher mean diffusivity in the cingulate gyrus, corpus callosum, upper corona, internal capsule, external capsule, fornix, and superior longitudinal fasciculus. CONCLUSION: Structural changes in the brain play a role in the condition of elderly IBS patients. Psychological stress is an important factor for developing IBS via the hypothalamic‐pituitary‐adrenal axis. John Wiley and Sons Inc. 2018-09-24 /pmc/articles/PMC6880712/ /pubmed/31942491 http://dx.doi.org/10.1002/agm2.12034 Text en © 2018 The Authors. Aging Medicine published by Beijing Hospital and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Zhao, Lanlan
Wang, Yuezhi
Zhang, Yu
Microstructural changes in the brain in elderly patients with irritable bowel syndrome
title Microstructural changes in the brain in elderly patients with irritable bowel syndrome
title_full Microstructural changes in the brain in elderly patients with irritable bowel syndrome
title_fullStr Microstructural changes in the brain in elderly patients with irritable bowel syndrome
title_full_unstemmed Microstructural changes in the brain in elderly patients with irritable bowel syndrome
title_short Microstructural changes in the brain in elderly patients with irritable bowel syndrome
title_sort microstructural changes in the brain in elderly patients with irritable bowel syndrome
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880712/
https://www.ncbi.nlm.nih.gov/pubmed/31942491
http://dx.doi.org/10.1002/agm2.12034
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