Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation

We report a new synthetic approach to assemble spirothiazolidinediones via a [2 + 2 + 2] cyclotrimerization reaction and the derivatives were further functionalized through DA chemistry and click reaction. Using flow cytometry, it was shown for the first time that the new benzyl alcohol derivatives...

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Detalles Bibliográficos
Autores principales: Kotha, Sambasivarao, Sreevani, Gaddamedi, Dzhemileva, Lilya U, Yunusbaeva, Milyausha M, Dzhemilev, Usein M, D’yakonov, Vladimir A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2019
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880819/
https://www.ncbi.nlm.nih.gov/pubmed/31807211
http://dx.doi.org/10.3762/bjoc.15.269
Descripción
Sumario:We report a new synthetic approach to assemble spirothiazolidinediones via a [2 + 2 + 2] cyclotrimerization reaction and the derivatives were further functionalized through DA chemistry and click reaction. Using flow cytometry, it was shown for the first time that the new benzyl alcohol derivatives of thiazolidine-2,4-dione generated here are efficient apoptosis inducers in the HeLa, Hek293, U937, Jurkat, and K562 cell lines.

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