Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation

We report a new synthetic approach to assemble spirothiazolidinediones via a [2 + 2 + 2] cyclotrimerization reaction and the derivatives were further functionalized through DA chemistry and click reaction. Using flow cytometry, it was shown for the first time that the new benzyl alcohol derivatives...

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Autores principales: Kotha, Sambasivarao, Sreevani, Gaddamedi, Dzhemileva, Lilya U, Yunusbaeva, Milyausha M, Dzhemilev, Usein M, D’yakonov, Vladimir A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2019
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880819/
https://www.ncbi.nlm.nih.gov/pubmed/31807211
http://dx.doi.org/10.3762/bjoc.15.269
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author Kotha, Sambasivarao
Sreevani, Gaddamedi
Dzhemileva, Lilya U
Yunusbaeva, Milyausha M
Dzhemilev, Usein M
D’yakonov, Vladimir A
author_facet Kotha, Sambasivarao
Sreevani, Gaddamedi
Dzhemileva, Lilya U
Yunusbaeva, Milyausha M
Dzhemilev, Usein M
D’yakonov, Vladimir A
author_sort Kotha, Sambasivarao
collection PubMed
description We report a new synthetic approach to assemble spirothiazolidinediones via a [2 + 2 + 2] cyclotrimerization reaction and the derivatives were further functionalized through DA chemistry and click reaction. Using flow cytometry, it was shown for the first time that the new benzyl alcohol derivatives of thiazolidine-2,4-dione generated here are efficient apoptosis inducers in the HeLa, Hek293, U937, Jurkat, and K562 cell lines.
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spelling pubmed-68808192019-12-05 Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation Kotha, Sambasivarao Sreevani, Gaddamedi Dzhemileva, Lilya U Yunusbaeva, Milyausha M Dzhemilev, Usein M D’yakonov, Vladimir A Beilstein J Org Chem Full Research Paper We report a new synthetic approach to assemble spirothiazolidinediones via a [2 + 2 + 2] cyclotrimerization reaction and the derivatives were further functionalized through DA chemistry and click reaction. Using flow cytometry, it was shown for the first time that the new benzyl alcohol derivatives of thiazolidine-2,4-dione generated here are efficient apoptosis inducers in the HeLa, Hek293, U937, Jurkat, and K562 cell lines. Beilstein-Institut 2019-11-18 /pmc/articles/PMC6880819/ /pubmed/31807211 http://dx.doi.org/10.3762/bjoc.15.269 Text en Copyright © 2019, Kotha et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Kotha, Sambasivarao
Sreevani, Gaddamedi
Dzhemileva, Lilya U
Yunusbaeva, Milyausha M
Dzhemilev, Usein M
D’yakonov, Vladimir A
Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation
title Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation
title_full Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation
title_fullStr Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation
title_full_unstemmed Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation
title_short Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation
title_sort diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880819/
https://www.ncbi.nlm.nih.gov/pubmed/31807211
http://dx.doi.org/10.3762/bjoc.15.269
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