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An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent

Background: The carboxylesterase Notum has been shown to act as a key negative regulator of the Wnt signalling pathway by mediating the depalmitoleoylation of Wnt proteins. LP-922056 (1) is an orally active inhibitor of Notum. We are investigating the role of Notum in modulating Wnt signalling in th...

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Detalles Bibliográficos
Autores principales:	Willis, Nicky J, Bayle, Elliott D, Papageorgiou, George, Steadman, David, Atkinson, Benjamin N, Mahy, William, Fish, Paul V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2019
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880826/ https://www.ncbi.nlm.nih.gov/pubmed/31807213 http://dx.doi.org/10.3762/bjoc.15.271

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