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Design, synthesis and investigation of water-soluble hemi-indigo photoswitches for bioapplications
A series of hemi-indigo derivatives was synthesized and their photoswitching properties in aqueous medium were studied. The dimethoxy hemi-indigo derivative with the best photochromic performance in water was identified as a promising platform for the development of photoswitchable binders for biomo...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Beilstein-Institut
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880827/ https://www.ncbi.nlm.nih.gov/pubmed/31807217 http://dx.doi.org/10.3762/bjoc.15.275 |
| Sumario: | A series of hemi-indigo derivatives was synthesized and their photoswitching properties in aqueous medium were studied. The dimethoxy hemi-indigo derivative with the best photochromic performance in water was identified as a promising platform for the development of photoswitchable binders for biomolecules. The synthetic approach towards the introduction of the alkylamino pendant to the dimethoxy hemi-indigo core was developed that allowed to obtain an RNA-binding hemi-indigo derivative with photoswitchable fluorescent properties. |
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