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Design, synthesis and investigation of water-soluble hemi-indigo photoswitches for bioapplications

A series of hemi-indigo derivatives was synthesized and their photoswitching properties in aqueous medium were studied. The dimethoxy hemi-indigo derivative with the best photochromic performance in water was identified as a promising platform for the development of photoswitchable binders for biomo...

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Autor principal: Berdnikova, Daria V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880827/
https://www.ncbi.nlm.nih.gov/pubmed/31807217
http://dx.doi.org/10.3762/bjoc.15.275
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author Berdnikova, Daria V
author_facet Berdnikova, Daria V
author_sort Berdnikova, Daria V
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description A series of hemi-indigo derivatives was synthesized and their photoswitching properties in aqueous medium were studied. The dimethoxy hemi-indigo derivative with the best photochromic performance in water was identified as a promising platform for the development of photoswitchable binders for biomolecules. The synthetic approach towards the introduction of the alkylamino pendant to the dimethoxy hemi-indigo core was developed that allowed to obtain an RNA-binding hemi-indigo derivative with photoswitchable fluorescent properties.
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spelling pubmed-68808272019-12-05 Design, synthesis and investigation of water-soluble hemi-indigo photoswitches for bioapplications Berdnikova, Daria V Beilstein J Org Chem Full Research Paper A series of hemi-indigo derivatives was synthesized and their photoswitching properties in aqueous medium were studied. The dimethoxy hemi-indigo derivative with the best photochromic performance in water was identified as a promising platform for the development of photoswitchable binders for biomolecules. The synthetic approach towards the introduction of the alkylamino pendant to the dimethoxy hemi-indigo core was developed that allowed to obtain an RNA-binding hemi-indigo derivative with photoswitchable fluorescent properties. Beilstein-Institut 2019-11-22 /pmc/articles/PMC6880827/ /pubmed/31807217 http://dx.doi.org/10.3762/bjoc.15.275 Text en Copyright © 2019, Berdnikova https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Berdnikova, Daria V
Design, synthesis and investigation of water-soluble hemi-indigo photoswitches for bioapplications
title Design, synthesis and investigation of water-soluble hemi-indigo photoswitches for bioapplications
title_full Design, synthesis and investigation of water-soluble hemi-indigo photoswitches for bioapplications
title_fullStr Design, synthesis and investigation of water-soluble hemi-indigo photoswitches for bioapplications
title_full_unstemmed Design, synthesis and investigation of water-soluble hemi-indigo photoswitches for bioapplications
title_short Design, synthesis and investigation of water-soluble hemi-indigo photoswitches for bioapplications
title_sort design, synthesis and investigation of water-soluble hemi-indigo photoswitches for bioapplications
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880827/
https://www.ncbi.nlm.nih.gov/pubmed/31807217
http://dx.doi.org/10.3762/bjoc.15.275
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