Cargando…

Serum Uric Acid – Risk Factor for Acute Ischemic Stroke and Poor Outcomes

Over the last decades several studies among the adult population have attempted to establish a correlation between the risk of stroke incidence and serum uric acid (SUA) concentration, and how these levels influence the patient’s neurological outcome after a stroke. But, to date, the results are con...

Descripción completa

Detalles Bibliográficos
Autores principales: Tariq, Muhammad Ali, Shamim, Sohaib A, Rana, Kiran F, Saeed, Aisha, Malik, Bilal Haider
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881082/
https://www.ncbi.nlm.nih.gov/pubmed/31815071
http://dx.doi.org/10.7759/cureus.6007
_version_ 1783473879341072384
author Tariq, Muhammad Ali
Shamim, Sohaib A
Rana, Kiran F
Saeed, Aisha
Malik, Bilal Haider
author_facet Tariq, Muhammad Ali
Shamim, Sohaib A
Rana, Kiran F
Saeed, Aisha
Malik, Bilal Haider
author_sort Tariq, Muhammad Ali
collection PubMed
description Over the last decades several studies among the adult population have attempted to establish a correlation between the risk of stroke incidence and serum uric acid (SUA) concentration, and how these levels influence the patient’s neurological outcome after a stroke. But, to date, the results are conflicting. In this review, an extensive literature search was performed through PubMed for articles published until May 2019 to review the association. The study selection was narrowed by searching PubMed database using the Medical Subject Headings (MesH) and associated keywords. Only articles conducted in English and on human subjects were included. We considered an article for this review if it had statistics on either the incidence, stroke mortality or post-stroke functional outcomes along with serum uric acid levels in adults. This review includes 21 articles with data of 33,580 cases of stroke and 1,100,888 participants. We can divide the articles reviewed into two separate cohorts of studies. One relates serum uric acid levels to stroke frequency and mortality, while the other is associated with serum uric acid and outcomes for stroke survivors. Based on our review, no significant relationship is observed with uric acid exhibiting protective effects on stroke outcome. Large clinical trials are advised to provide well-defined solutions to further assess the benefits of uric acid level lowering treatment in patients of vascular events, such as a stroke. However, we confidently report that increasing uric acid levels poses a higher risk for incidence of stroke.
format Online
Article
Text
id pubmed-6881082
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-68810822019-12-06 Serum Uric Acid – Risk Factor for Acute Ischemic Stroke and Poor Outcomes Tariq, Muhammad Ali Shamim, Sohaib A Rana, Kiran F Saeed, Aisha Malik, Bilal Haider Cureus Neurology Over the last decades several studies among the adult population have attempted to establish a correlation between the risk of stroke incidence and serum uric acid (SUA) concentration, and how these levels influence the patient’s neurological outcome after a stroke. But, to date, the results are conflicting. In this review, an extensive literature search was performed through PubMed for articles published until May 2019 to review the association. The study selection was narrowed by searching PubMed database using the Medical Subject Headings (MesH) and associated keywords. Only articles conducted in English and on human subjects were included. We considered an article for this review if it had statistics on either the incidence, stroke mortality or post-stroke functional outcomes along with serum uric acid levels in adults. This review includes 21 articles with data of 33,580 cases of stroke and 1,100,888 participants. We can divide the articles reviewed into two separate cohorts of studies. One relates serum uric acid levels to stroke frequency and mortality, while the other is associated with serum uric acid and outcomes for stroke survivors. Based on our review, no significant relationship is observed with uric acid exhibiting protective effects on stroke outcome. Large clinical trials are advised to provide well-defined solutions to further assess the benefits of uric acid level lowering treatment in patients of vascular events, such as a stroke. However, we confidently report that increasing uric acid levels poses a higher risk for incidence of stroke. Cureus 2019-10-28 /pmc/articles/PMC6881082/ /pubmed/31815071 http://dx.doi.org/10.7759/cureus.6007 Text en Copyright © 2019, Tariq et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
Tariq, Muhammad Ali
Shamim, Sohaib A
Rana, Kiran F
Saeed, Aisha
Malik, Bilal Haider
Serum Uric Acid – Risk Factor for Acute Ischemic Stroke and Poor Outcomes
title Serum Uric Acid – Risk Factor for Acute Ischemic Stroke and Poor Outcomes
title_full Serum Uric Acid – Risk Factor for Acute Ischemic Stroke and Poor Outcomes
title_fullStr Serum Uric Acid – Risk Factor for Acute Ischemic Stroke and Poor Outcomes
title_full_unstemmed Serum Uric Acid – Risk Factor for Acute Ischemic Stroke and Poor Outcomes
title_short Serum Uric Acid – Risk Factor for Acute Ischemic Stroke and Poor Outcomes
title_sort serum uric acid – risk factor for acute ischemic stroke and poor outcomes
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881082/
https://www.ncbi.nlm.nih.gov/pubmed/31815071
http://dx.doi.org/10.7759/cureus.6007
work_keys_str_mv AT tariqmuhammadali serumuricacidriskfactorforacuteischemicstrokeandpooroutcomes
AT shamimsohaiba serumuricacidriskfactorforacuteischemicstrokeandpooroutcomes
AT ranakiranf serumuricacidriskfactorforacuteischemicstrokeandpooroutcomes
AT saeedaisha serumuricacidriskfactorforacuteischemicstrokeandpooroutcomes
AT malikbilalhaider serumuricacidriskfactorforacuteischemicstrokeandpooroutcomes